{"id":"W4390194412","doi":"10.1002/alz.079188","title":"Microglial activation interacts with amyloid‐β to drive longitudinal tau tangle accumulation and cognitive decline","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cuneus; Tangle; Neuroscience; Psychology; Cognitive decline; Neurofibrillary tangle; Neuroinflammation; Cognition; Internal medicine; Alzheimer's disease; Medicine; Senile plaques; Precuneus; Dementia; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006066814,0.0003109862,0.0004993013,0.000548575,0.0003742151,0.0005403063,0.0002046735,0.0003956911,0.001467449],"category_scores_gemma":[0.001015222,0.0002181647,0.0005401943,0.0003926569,0.0002708231,0.0002781344,0.0003392454,0.000398169,0.000262494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004067844,"about_ca_system_score_gemma":0.0003185615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003558824,"about_ca_topic_score_gemma":0.00421565,"domain_scores_codex":[0.9997503,0.00006927927,0.00001585846,0.00007681566,0.00004099055,0.00004670717],"domain_scores_gemma":[0.9995468,0.00009065961,0.0001650915,0.00005190032,0.000087284,0.00005808559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003042762,0.0003628209,0.8736962,0.0001982092,0.00075412,0.001156387,0.0005958203,0.001039533,0.1007667,0.0003565205,0.0007039865,0.01732693],"study_design_scores_gemma":[0.00002650027,0.0003353731,0.9914529,0.00002113739,0.0001684501,0.000922686,0.0001937763,0.001592891,0.004303074,0.0005967405,0.0003750868,0.00001128751],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979698,0.0005716581,0.0006259522,0.00006503407,0.000006312844,0.000007569556,0.0002187336,0.00001786533,0.000517027],"genre_scores_gemma":[0.9992394,0.0001093015,0.0002992255,0.00001896591,0.000006042152,0.00001148915,0.0001172177,0.000003171596,0.0001950638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003558824,"threshold_uncertainty_score":0.007076204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0707132570009438,"score_gpt":0.3205482849167209,"score_spread":0.2498350279157771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}