{"id":"W4390194686","doi":"10.1002/advs.202301358","title":"Mesoporous Silica Nanoparticles Mediate SiRNA Delivery for Long‐Term Multi‐Gene Silencing in Intact Plants","year":2023,"lang":"en","type":"article","venue":"Advanced Science","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics and Developmental Biology, Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Genetics; National Natural Science Foundation of China","keywords":"Gene silencing; RNA interference; Gene knockdown; Small interfering RNA; Cell biology; Biology; Phytoene desaturase; Chemistry; Gene; RNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003809648,0.0001485375,0.0001437204,0.0001414561,0.000155681,0.00003379835,0.0004636353,0.0000647269,0.000003704053],"category_scores_gemma":[0.0002169978,0.0001404572,0.00005420074,0.0003777785,0.0001960106,0.00003759577,0.0001858077,0.00006455981,0.00003493651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003565866,"about_ca_system_score_gemma":0.0001433676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001710602,"about_ca_topic_score_gemma":0.0002235292,"domain_scores_codex":[0.9984385,0.0000193265,0.0002409014,0.0005635811,0.0001936485,0.0005439881],"domain_scores_gemma":[0.9993635,0.0000392357,0.0000740456,0.0003143711,0.0000945412,0.0001143043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007957382,0.0000301787,0.006631093,0.00000901608,0.000004867186,0.00001589582,0.0001699607,0.001218346,0.9771402,0.000003069422,0.00003939669,0.01465837],"study_design_scores_gemma":[0.0005762892,0.000220887,0.05190593,0.0000320554,0.000003229726,0.000007953646,0.0001763095,0.001387744,0.9453932,0.0000459656,0.00006212739,0.0001883191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985031,0.0004069922,0.0004150589,0.00004884979,0.0003031881,0.0002336819,0.00002879493,0.00003197601,0.00002836391],"genre_scores_gemma":[0.9979931,0.0006086664,0.0008993002,0.0001817407,0.00005945061,0.00006233124,0.00004527623,0.00001413406,0.0001359889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04527484,"threshold_uncertainty_score":0.572768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02273536717021922,"score_gpt":0.3048159540801777,"score_spread":0.2820805869099585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}