{"id":"W4390194925","doi":"10.1002/alz.079855","title":"CSF total tau is more closely associated with synaptic dysfunction than overt neurodegeneration","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Toronto; McGill University Health Centre; Sunnybrook Health Science Centre; Douglas Mental Health University Institute; McGill University","funders":"","keywords":"Neurodegeneration; Binding potential; Internal medicine; Standardized uptake value; Magnetic resonance imaging; Psychology; Medicine; Cognitive decline; Hippocampal formation; Neuroscience; Oncology; Positron emission tomography; Endocrinology; Pathology; Dementia; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000617544,0.0005853335,0.0003917683,0.0008397235,0.0003690727,0.0007057226,0.0004194287,0.0003019506,0.002110658],"category_scores_gemma":[0.00312925,0.0002061359,0.0003035155,0.0007156978,0.0004471854,0.0002399512,0.0004109553,0.0003504182,0.0002139971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000377785,"about_ca_system_score_gemma":0.0004795061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01986538,"about_ca_topic_score_gemma":0.02593416,"domain_scores_codex":[0.9997061,0.00005906472,0.00003932304,0.00008120455,0.00006088224,0.00005332985],"domain_scores_gemma":[0.9975972,0.000442421,0.001129858,0.0002393279,0.0002825607,0.0003086949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000223878,0.00001553919,0.9974988,0.00000827433,0.00008112553,0.0001317903,0.00003411204,0.00008061805,0.0007122444,0.00001165007,0.00005288987,0.001148923],"study_design_scores_gemma":[0.000003801742,0.00005649692,0.9989229,0.000005267716,0.00003110729,0.0003661107,0.00004998099,0.0003135281,0.0001454411,0.00005661881,0.00004653763,0.000002082547],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995437,0.0001112157,0.00007632912,0.00001357985,0.000002491749,0.000001877018,0.00008094473,0.000003099241,0.0001667006],"genre_scores_gemma":[0.9997161,0.0000305526,0.00005027165,0.000007350597,0.000004069183,0.000001592888,0.00009544571,0.000001525727,0.00009313286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01986538,"threshold_uncertainty_score":0.03949952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02734724700924923,"score_gpt":0.2877832028348233,"score_spread":0.2604359558255741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}