{"id":"W4390195036","doi":"10.1002/alz.080116","title":"Associations of GFAP, NfL, Aβ42/40, and pTau231 with global cognition in LEADS","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Clinical Dementia Rating; Montreal Cognitive Assessment; Cognition; Biomarker; Dementia; Internal medicine; Psychology; Neuropsychology; Glial fibrillary acidic protein; Cognitive decline; Cognitive impairment; Medicine; Audiology; Clinical psychology; Oncology; Psychiatry; Disease; Chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004470618,0.0004351987,0.000353856,0.0008708286,0.0005979024,0.0009876878,0.0002604145,0.0003458676,0.001674959],"category_scores_gemma":[0.0009749904,0.0001943512,0.0005122542,0.0007900331,0.0003573399,0.0002506786,0.0004418906,0.0003215662,0.0002644786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003590106,"about_ca_system_score_gemma":0.0002133814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005211177,"about_ca_topic_score_gemma":0.00995536,"domain_scores_codex":[0.9997751,0.00003753889,0.00003135254,0.00007564804,0.00003611516,0.00004429532],"domain_scores_gemma":[0.9993037,0.0001029893,0.0002794404,0.00008558801,0.0001031913,0.0001250568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004867799,0.00003936839,0.9961265,0.00001256932,0.00008269289,0.0003204581,0.0001941631,0.00005774353,0.001174918,0.00002991085,0.00006936186,0.001405543],"study_design_scores_gemma":[0.000007747279,0.0001025412,0.9983634,0.000005018077,0.00006230176,0.0005085504,0.0001917167,0.00008327703,0.0004287707,0.0000987004,0.0001448906,0.000003088457],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992821,0.00008464433,0.00005747177,0.000009289568,0.000001999157,0.000002868266,0.0002117032,0.00000365127,0.0003463421],"genre_scores_gemma":[0.9994764,0.00003407922,0.00004120382,0.00001008724,0.000003097282,0.000003905569,0.0002287937,0.000001802722,0.0002006245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005211177,"threshold_uncertainty_score":0.01036167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03987123367172728,"score_gpt":0.3381779716376029,"score_spread":0.2983067379658756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}