{"id":"W4390195359","doi":"10.1002/alz.076691","title":"Plasma p‐tau231 and p‐tau217 provides information on tau tangle deposition in symptomatic Alzheimer’s disease individuals","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"","keywords":"Biomarker; Glial fibrillary acidic protein; Demographics; Psychology; Cohort; Tau protein; Internal medicine; Amyloid (mycology); Pathology; Neurofibrillary tangle; Oncology; Alzheimer's disease; Disease; Medicine; Nuclear medicine; Neuroscience; Chemistry; Senile plaques; Biochemistry; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000488294,0.0004882318,0.0003426634,0.001008677,0.0002635675,0.000528424,0.0002263342,0.0004051028,0.001743278],"category_scores_gemma":[0.001446319,0.0002131514,0.0002455232,0.0003765018,0.0002123333,0.0002601296,0.0002377921,0.0002586709,0.0002802225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002442163,"about_ca_system_score_gemma":0.0001421353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004106108,"about_ca_topic_score_gemma":0.003850576,"domain_scores_codex":[0.9998479,0.00003544634,0.000018764,0.00004302022,0.0000298506,0.00002506764],"domain_scores_gemma":[0.9995183,0.0001182616,0.0001504329,0.00004222196,0.00007416873,0.00009661754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001403655,0.00007051264,0.9750988,0.00002943589,0.0001318765,0.000419097,0.0001853883,0.000220809,0.01570746,0.00003117239,0.0001415838,0.006560171],"study_design_scores_gemma":[0.000007656829,0.0001821725,0.997188,0.000004132121,0.00003985635,0.00065442,0.00007267992,0.0003676299,0.001353896,0.00004353247,0.00008200954,0.000004018793],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994563,0.0001618193,0.00008697233,0.000009432077,0.000001392883,0.000001993459,0.00009823042,0.000005657538,0.0001781499],"genre_scores_gemma":[0.9996678,0.00003612572,0.00008540691,0.000005873098,0.000003045162,0.000002279123,0.00009338618,0.000001135414,0.0001049345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004106108,"threshold_uncertainty_score":0.008164406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02488960525794994,"score_gpt":0.2994935570141045,"score_spread":0.2746039517561546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}