{"id":"W4390195478","doi":"10.1002/alz.076052","title":"GM1 modulates amyloid‐beta activation of NLRP3 inflammasome in microglia through Akt/mTOR‐mediated regulation of autophagy","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Microglia; Neuroinflammation; Inflammasome; Autophagy; Neuroprotection; PI3K/AKT/mTOR pathway; Neurodegeneration; Cell biology; Amyloid beta; Inflammation; mTORC1; Biology; Signal transduction; Chemistry; Neuroscience; Immunology; Medicine; Internal medicine; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001795511,0.0003739649,0.0004500772,0.0002677745,0.0002510242,0.0003900714,0.0002383301,0.0003629505,0.0022074],"category_scores_gemma":[0.00007749515,0.0001437252,0.000455496,0.0002167655,0.0002887099,0.0003113677,0.0002790026,0.0007402022,0.0006593677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004726183,"about_ca_system_score_gemma":0.0004262526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005413949,"about_ca_topic_score_gemma":0.0007503372,"domain_scores_codex":[0.9998853,0.00001876997,0.00001454338,0.00002170155,0.00002131292,0.00003826481],"domain_scores_gemma":[0.9999537,0.000003517477,0.00001639978,0.000004075542,0.000008915013,0.00001331039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002749548,0.0001705875,0.0004764489,0.0007401682,0.00004029032,0.0001587093,0.00004995201,0.0001949501,0.9912588,0.0003852189,0.0005671163,0.003208188],"study_design_scores_gemma":[0.0005293075,0.001443114,0.02262316,0.0001248036,0.0001712266,0.0006346383,0.0002141682,0.002338343,0.9605271,0.0008380398,0.01052355,0.00003248818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787839,0.01266744,0.001407187,0.0007689422,0.000170194,0.00007823305,0.001849014,0.0001395259,0.004135437],"genre_scores_gemma":[0.9877429,0.006100525,0.001909998,0.0002740652,0.00005650662,0.000154143,0.000895231,0.00002142282,0.00284514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0022074,"threshold_uncertainty_score":0.007384479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02064603989467832,"score_gpt":0.2555942593074191,"score_spread":0.2349482194127408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}