{"id":"W4390196252","doi":"10.1002/alz.075711","title":"SUMOylation impact on synaptotoxicity of tau oligomers","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"SUMO protein; Long-term potentiation; Genetically modified mouse; Transgene; Neuroscience; Biology; Cell biology; Gene isoform; Hippocampus; Synapse; Cognitive decline; Ubiquitin; Biochemistry; Disease; Medicine; Internal medicine; Dementia; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138513,0.0003765126,0.0002691905,0.0001921608,0.0001478472,0.0003197028,0.0001228423,0.0002503965,0.001504444],"category_scores_gemma":[0.00008969661,0.0001080393,0.0002856092,0.0001370177,0.000179015,0.000189895,0.0001960949,0.0003369277,0.0002455209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000165251,"about_ca_system_score_gemma":0.0001231394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004147907,"about_ca_topic_score_gemma":0.000384776,"domain_scores_codex":[0.9999154,0.00001105071,0.0000102713,0.00001732884,0.00002397559,0.00002203271],"domain_scores_gemma":[0.9998912,0.00001278368,0.00003149212,0.0000131279,0.00002072926,0.00003067313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002513141,0.0000248235,0.0003647793,0.00003816741,0.00001065402,0.00007633121,0.000008667877,0.00002633334,0.9987125,0.00004034793,0.00001184462,0.0004343253],"study_design_scores_gemma":[0.00001566092,0.0004775854,0.009348801,0.000006836814,0.00002918405,0.0003397742,0.00002945806,0.0003242162,0.9888076,0.00005848314,0.0005587963,0.000003465525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977106,0.0009787269,0.0004695475,0.00002266959,0.00001288566,0.00001029116,0.0001666544,0.00001316588,0.0006154972],"genre_scores_gemma":[0.9978248,0.0006127077,0.0002826591,0.00002173196,0.000004380788,0.00001035779,0.000223339,0.000005507954,0.001014473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504444,"threshold_uncertainty_score":0.005032897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02501440540726031,"score_gpt":0.2891321595840289,"score_spread":0.2641177541767686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}