{"id":"W4390196994","doi":"10.1002/alz.081881","title":"Microglial activation interacts with amyloid‐β to drive longitudinal tau tangle accumulation and cognitive decline","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cuneus; Tangle; Neuroscience; Psychology; Cognitive decline; Neurofibrillary tangle; Neuroinflammation; Cognition; Internal medicine; Alzheimer's disease; Medicine; Senile plaques; Precuneus; Dementia; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005904304,0.0003032618,0.0004853702,0.000532381,0.0003676703,0.0005427079,0.000197116,0.0003869516,0.001464575],"category_scores_gemma":[0.001017858,0.0002133978,0.0005228718,0.0003847512,0.000263862,0.0002758329,0.0003379653,0.0004017902,0.0002617682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004025904,"about_ca_system_score_gemma":0.0003133445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003446636,"about_ca_topic_score_gemma":0.004018276,"domain_scores_codex":[0.9997612,0.00006583742,0.0000154526,0.0000726279,0.00003977442,0.00004502208],"domain_scores_gemma":[0.9995478,0.00009084855,0.0001641742,0.00005225678,0.00008713587,0.00005781695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002877656,0.000356051,0.8771231,0.0001826941,0.0006890736,0.001097909,0.0005793341,0.00101276,0.09809749,0.0003531133,0.0006728448,0.01695789],"study_design_scores_gemma":[0.00002488141,0.0003252669,0.9915542,0.00001987212,0.0001537289,0.0009177616,0.0001913057,0.001579156,0.004265707,0.0005970004,0.0003603255,0.00001091647],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980901,0.0005277594,0.0005833047,0.00006145073,0.000006052898,0.000006964744,0.0002079119,0.00001698862,0.000499518],"genre_scores_gemma":[0.9992551,0.000104062,0.0002915416,0.0000181419,0.00000606622,0.00001122435,0.0001163065,0.000003027161,0.0001943453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003446636,"threshold_uncertainty_score":0.006853163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0707132570009438,"score_gpt":0.3205482849167209,"score_spread":0.2498350279157771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}