{"id":"W4390198322","doi":"10.1002/alz.081943","title":"CSF total tau is more closely associated with synaptic dysfunction than overt neurodegeneration","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Toronto; McGill University Health Centre; Sunnybrook Health Science Centre; Douglas Mental Health University Institute; McGill University","funders":"","keywords":"Neurodegeneration; Binding potential; Internal medicine; Standardized uptake value; Psychology; Magnetic resonance imaging; Cognitive decline; Medicine; Hippocampal formation; Neuroscience; Oncology; Endocrinology; Positron emission tomography; Dementia; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000603209,0.0005806313,0.000381101,0.0008304829,0.0003706909,0.0006871845,0.0004116051,0.00029762,0.002069142],"category_scores_gemma":[0.002994441,0.0001980478,0.0003059466,0.0007011053,0.0004295195,0.0002378831,0.0004099452,0.000345733,0.0002087845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003793768,"about_ca_system_score_gemma":0.0004720083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01994412,"about_ca_topic_score_gemma":0.02595883,"domain_scores_codex":[0.9997166,0.00005689968,0.00003811974,0.00007791281,0.00005892755,0.00005155157],"domain_scores_gemma":[0.9977407,0.000416268,0.001051779,0.0002244139,0.0002727402,0.0002940153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002136795,0.00001490571,0.9976125,0.000007836516,0.00007706546,0.0001263546,0.00003260777,0.00007738206,0.0006724748,0.00001153006,0.00005068243,0.001103085],"study_design_scores_gemma":[0.000003797737,0.00005720819,0.9989151,0.000005288252,0.00003113893,0.0003653173,0.00005048254,0.0003192262,0.0001466683,0.00005647455,0.00004722497,0.000002054347],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995528,0.0001097622,0.00007361374,0.0000131865,0.000002420451,0.000001859175,0.00008095682,0.000003024848,0.0001624643],"genre_scores_gemma":[0.999713,0.00003111294,0.00005049117,0.00000732043,0.000004131544,0.000001638201,0.00009865189,0.000001484992,0.00009214073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01994412,"threshold_uncertainty_score":0.0396561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02734724700924923,"score_gpt":0.2877832028348233,"score_spread":0.2604359558255741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}