{"id":"W4390198333","doi":"10.1002/alz.081939","title":"Synapse dysfunction and astrocyte reactivity are associated independently of amyloid‐β and tau pathologies","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; McGill University Health Centre","funders":"","keywords":"Astrocyte; Glial fibrillary acidic protein; Neurogranin; Biomarker; Neuroscience; Synaptotagmin 1; Synaptic plasticity; Postsynaptic potential; Medicine; Internal medicine; Psychology; Biology; Receptor; Central nervous system; Cell biology; Synaptic vesicle; Biochemistry; Immunohistochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000302189,0.0005816862,0.0003255929,0.0007804935,0.0003223034,0.0005674338,0.0003195489,0.0004233087,0.001795563],"category_scores_gemma":[0.001209432,0.0002649515,0.0002716776,0.0005036141,0.0002979267,0.0002044326,0.000432874,0.0004974408,0.0002796446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207514,"about_ca_system_score_gemma":0.0002306155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005621561,"about_ca_topic_score_gemma":0.00717213,"domain_scores_codex":[0.9998,0.00003463886,0.00001935308,0.00006139794,0.00004282329,0.00004190927],"domain_scores_gemma":[0.9988992,0.0001042051,0.0005309235,0.0001020109,0.0001178361,0.000245688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000574904,0.00003778238,0.9895801,0.00001497089,0.0001378174,0.000702881,0.00007403437,0.00003515826,0.007181114,0.00003339362,0.0001038076,0.001523957],"study_design_scores_gemma":[0.000003376985,0.00004403295,0.9988417,0.000002339334,0.00002674488,0.000678845,0.00001911709,0.00006155116,0.0002608121,0.00002584504,0.00003393238,0.000001752705],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994822,0.0001577131,0.00004733657,0.00001359293,0.000003458994,0.000002207754,0.00008836824,0.000004459976,0.0002006988],"genre_scores_gemma":[0.9996573,0.00003886954,0.00004675559,0.000008395039,0.000005430106,0.000002332891,0.00009976447,0.000001790813,0.0001393661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005621561,"threshold_uncertainty_score":0.01117766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03488242831243225,"score_gpt":0.2937888325708386,"score_spread":0.2589064042584063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}