{"id":"W4390198527","doi":"10.1002/alz.077554","title":"Validated, unified theory of Alzheimer Disease illuminates two essential research questions","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alcoholism and Thiamine Deficiency","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Manitoba Beekeepers' Association","funders":"","keywords":"Thiamine; Alzheimer's disease; Disease; Medicine; Thiamine deficiency; Internal medicine; Neuroscience; Physiology; Endocrinology; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001884773,0.0002327827,0.0003528086,0.0005855257,0.0002858778,0.0000346537,0.000278314,0.00009592645,0.0007704795],"category_scores_gemma":[0.0002522453,0.0002021719,0.000184481,0.001397317,0.0006195349,0.0001657399,0.0002783964,0.0003581804,0.0008738841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005075167,"about_ca_system_score_gemma":0.0002265183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001804356,"about_ca_topic_score_gemma":0.0000056595,"domain_scores_codex":[0.9970984,0.0004011421,0.0004944787,0.0004932117,0.0008514434,0.0006613061],"domain_scores_gemma":[0.9980644,0.0002540782,0.0001115635,0.000790557,0.0004496448,0.0003297815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003972528,0.005640293,0.04991919,0.0003520278,0.07431008,0.002053509,0.005966709,0.0002313563,0.1376025,0.5343781,0.09936821,0.0862055],"study_design_scores_gemma":[0.01071027,0.001569477,0.2417827,0.0006050173,0.1595556,0.00009086195,0.003497529,0.002206762,0.5179127,0.0355559,0.02473917,0.001774038],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8572791,0.1213007,0.0004012552,0.002689182,0.001268362,0.001880352,0.0001799884,0.0006544203,0.0143466],"genre_scores_gemma":[0.9984687,0.0002782569,0.0002444631,0.00008127205,0.0002021409,0.00007898937,0.0004046282,0.00005633534,0.0001851956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4988222,"threshold_uncertainty_score":0.999904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0865768442055328,"score_gpt":0.3839002575098297,"score_spread":0.2973234133042969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}