{"id":"W4390198629","doi":"10.1002/alz.072776","title":"Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Helmholtz Zentrum München; Canadian Institutes of Health Research; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; Northern California Institute for Research and Education; Hjartavernd; CurePSP; Servier; Eisai; Bundesministerium für Bildung und Forschung; H. Lundbeck A/S; Rush University; Mayo Foundation for Medical Education and Research; University of Southern California; Pfizer; BioClinica; Biogen; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"Bioenergetics; Biomarker; Cognition; Cognitive decline; Disease; Neuroimaging; Psychology; Effects of sleep deprivation on cognitive performance; Biology; Neuroscience; Internal medicine; Medicine; Dementia; Mitochondrion; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008341213,0.0003737687,0.0005893484,0.001067587,0.0004244678,0.0007509431,0.0003544933,0.0003840335,0.001313461],"category_scores_gemma":[0.002366439,0.0001263745,0.0007080106,0.0008194279,0.0003949576,0.000376791,0.0006614635,0.0003749371,0.0001520526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002556162,"about_ca_system_score_gemma":0.0002945022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002572222,"about_ca_topic_score_gemma":0.002186611,"domain_scores_codex":[0.9996254,0.0001161196,0.00003410037,0.0001281692,0.00004859441,0.00004756797],"domain_scores_gemma":[0.9986767,0.0003286905,0.0003776752,0.0003455172,0.0001279069,0.0001435345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001022676,0.0000855708,0.9724392,0.00005345776,0.0009619227,0.0001278201,0.0006486925,0.00084888,0.01067765,0.0003544145,0.000197798,0.01258188],"study_design_scores_gemma":[0.000004355931,0.0001135249,0.9968989,0.000008735869,0.0001219158,0.0001135598,0.0002532784,0.0009681385,0.0005203686,0.0008250732,0.0001627266,0.000009590753],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987887,0.000142987,0.0005979692,0.00004244272,0.000003499408,0.000005640381,0.0001791476,0.000009706774,0.0002299812],"genre_scores_gemma":[0.9994919,0.00003089126,0.0002722077,0.000007655783,0.000003412501,0.000003289915,0.0001352058,0.000002778532,0.0000526169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002572222,"threshold_uncertainty_score":0.005114555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02425390953869652,"score_gpt":0.268409683851724,"score_spread":0.2441557743130275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}