{"id":"W4390198751","doi":"10.1002/alz.081726","title":"Plasma p‐tau231 and p‐tau217 provides information on tau tangle deposition in symptomatic Alzheimer’s disease individuals","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"","keywords":"Biomarker; Glial fibrillary acidic protein; Demographics; Cohort; Psychology; Internal medicine; Tau protein; Amyloid (mycology); Neurofibrillary tangle; Pathology; Oncology; Disease; Medicine; Alzheimer's disease; Neuroscience; Endocrinology; Chemistry; Senile plaques; Biochemistry; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004849309,0.0004846134,0.0003315162,0.001014095,0.0002658039,0.0005226416,0.0002207137,0.0004065855,0.001748486],"category_scores_gemma":[0.001466373,0.0002082662,0.0002464489,0.0003718219,0.000211701,0.0002661463,0.000242577,0.0002572406,0.0002740141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427132,"about_ca_system_score_gemma":0.0001429369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004155859,"about_ca_topic_score_gemma":0.003931833,"domain_scores_codex":[0.999854,0.00003492941,0.00001791309,0.00003972011,0.00002894709,0.00002448775],"domain_scores_gemma":[0.9995222,0.0001210682,0.0001441229,0.00004072515,0.0000741843,0.00009756356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001250862,0.00006254247,0.978475,0.00002636796,0.0001183284,0.000393106,0.0001757461,0.0002054574,0.01331824,0.00002957226,0.0001296085,0.005815209],"study_design_scores_gemma":[0.000007308221,0.0001726956,0.9973302,0.000004042801,0.00003798975,0.0006525482,0.00007270892,0.0003725744,0.001227432,0.00004234608,0.0000761688,0.000003911581],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994795,0.000153816,0.00007891293,0.000009017181,0.000001333682,0.000001920264,0.00009013058,0.000005288163,0.0001801492],"genre_scores_gemma":[0.9996816,0.0000341996,0.00008120379,0.000005648483,0.000002968116,0.000002218404,0.00008903705,0.000001057214,0.0001020015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004155859,"threshold_uncertainty_score":0.00826329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02488960525794994,"score_gpt":0.2994935570141045,"score_spread":0.2746039517561546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}