{"id":"W4390198854","doi":"10.1002/alz.074162","title":"Relationships between polymorphisms in keratin genes and Alzheimer’s disease phenotypes.","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Dementia Research Alliance; Toronto Rehabilitation Institute; Sunnybrook Health Science Centre; Heart and Stroke Foundation; Centre for Addiction and Mental Health","funders":"","keywords":"Single-nucleotide polymorphism; Minor allele frequency; Genetics; Alzheimer's disease; Biology; Genome-wide association study; Hyperintensity; Pathology; Medicine; Gene; Genotype; Disease; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004436353,0.000158227,0.0001333189,0.0001125813,0.0001595535,0.00003002269,0.0001747259,0.0001563289,0.0000572885],"category_scores_gemma":[0.0000508284,0.000157087,0.00005315774,0.0002231063,0.0001354772,0.000006445652,0.0002270266,0.0001550103,0.0001301828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001458299,"about_ca_system_score_gemma":0.00006716958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003859299,"about_ca_topic_score_gemma":0.0000497434,"domain_scores_codex":[0.9986563,0.0002020258,0.000222246,0.0004276446,0.0001308479,0.0003609623],"domain_scores_gemma":[0.9993962,0.00003553988,0.00004256464,0.000314991,0.00003091592,0.0001797838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007571779,0.00004703307,0.9091488,0.000002707533,0.002790942,0.00005127646,0.0000735549,0.00001514816,0.04421536,0.0003114759,0.003332354,0.03993565],"study_design_scores_gemma":[0.0009526623,0.0001267078,0.8701555,0.00001252869,0.002421299,0.000008455951,0.00008410504,0.0001742068,0.1022688,0.0006794342,0.02262337,0.0004929149],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8203862,0.1779721,0.00007067106,0.000657665,0.0001096149,0.0002917818,0.0000326413,0.0000345047,0.0004448211],"genre_scores_gemma":[0.9978082,0.0007873845,0.0002150937,0.00006652326,0.0001924204,0.00005390387,0.0007907931,0.00002701458,0.0000586312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.177422,"threshold_uncertainty_score":0.6405821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05255894948872792,"score_gpt":0.296450062962451,"score_spread":0.2438911134737231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}