{"id":"W4390198854","doi":"10.1002/alz.074162","title":"Relationships between polymorphisms in keratin genes and Alzheimer’s disease phenotypes.","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Dementia Research Alliance; Toronto Rehabilitation Institute; Sunnybrook Health Science Centre; Heart and Stroke Foundation; Centre for Addiction and Mental Health","funders":"","keywords":"Single-nucleotide polymorphism; Minor allele frequency; Genetics; Alzheimer's disease; Biology; Genome-wide association study; Hyperintensity; Pathology; Medicine; Gene; Genotype; Disease; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004985007,0.0003580845,0.0002978565,0.0008135751,0.0003885701,0.0003899946,0.0002405328,0.0004862174,0.003514817],"category_scores_gemma":[0.001288173,0.0001823875,0.0004506013,0.001224763,0.0002267396,0.0001654712,0.0002159006,0.0003980457,0.0003045526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001362646,"about_ca_system_score_gemma":0.0001316176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002085704,"about_ca_topic_score_gemma":0.002188393,"domain_scores_codex":[0.9996108,0.00009555559,0.00006131231,0.0001387269,0.00004795571,0.00004563746],"domain_scores_gemma":[0.9990195,0.0003833317,0.0003231064,0.00006261852,0.00008069476,0.0001306468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00188757,0.00009501029,0.9870789,0.0000759523,0.0005742127,0.0006180411,0.00008694572,0.0001697297,0.005530245,0.0000788592,0.000340947,0.003463491],"study_design_scores_gemma":[0.00003702662,0.0001642233,0.996955,0.0000132273,0.000235412,0.001034223,0.00004831646,0.0003522643,0.0005717779,0.0001569198,0.0004258599,0.00000572232],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971905,0.0008007886,0.000242401,0.00004999767,0.00001885661,0.00001327231,0.001165116,0.00001212897,0.0005069236],"genre_scores_gemma":[0.9988365,0.0001184491,0.0003246248,0.00002249812,0.00001277196,0.00001339663,0.0003498927,0.000004328922,0.0003176115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003514817,"threshold_uncertainty_score":0.01175827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05255894948872792,"score_gpt":0.296450062962451,"score_spread":0.2438911134737231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}