{"id":"W4390199190","doi":"10.1002/alz.073726","title":"Association between lipopolysaccharide, immune biomarkers and cerebral amyloid‐beta deposition in older adults with mild cognitive impairment & major depressive disorder","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; Baycrest Hospital; Pediatric Oncology Group; Toronto Dementia Research Alliance; University of Toronto; University Health Network; St. Michael's Hospital; Sunnybrook Health Science Centre; Sunnybrook Hospital","funders":"","keywords":"Internal medicine; Medicine; Cognitive decline; Lipopolysaccharide binding protein; Major depressive disorder; C-reactive protein; Depression (economics); Proinflammatory cytokine; Immunology; Inflammation; Endocrinology; Gastroenterology; Acute-phase protein; Dementia; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003466503,0.0002739645,0.0003657598,0.0005513721,0.0003513773,0.0005085354,0.0002006909,0.0003831515,0.001137389],"category_scores_gemma":[0.001385766,0.0001861287,0.0002751949,0.0004903355,0.0001653506,0.0001917854,0.0002684322,0.0003980905,0.0001589021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002043975,"about_ca_system_score_gemma":0.0001503324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003725486,"about_ca_topic_score_gemma":0.004745893,"domain_scores_codex":[0.9998239,0.00004105577,0.0000345632,0.00004225316,0.0000320494,0.000026202],"domain_scores_gemma":[0.9993081,0.0001060264,0.0003202259,0.00003337868,0.0000993373,0.0001329767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001280733,0.00002978855,0.99887,0.000009861226,0.00006134287,0.00005640837,0.00002174975,0.00001305047,0.0001541733,0.000004960054,0.00005244563,0.0005981975],"study_design_scores_gemma":[0.000006786905,0.00005497516,0.9995891,0.000003496699,0.00002805595,0.0001358076,0.00003497258,0.0000773332,0.00002391509,0.000009084005,0.00003547108,0.000001022864],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991922,0.0003667308,0.00002791017,0.00003578338,0.000005828933,0.000004558631,0.0001905262,0.000001588952,0.0001749022],"genre_scores_gemma":[0.9996674,0.00007623482,0.00003561633,0.00002027147,0.000007767198,0.000003680073,0.000115151,3.000729e-7,0.00007364697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003725486,"threshold_uncertainty_score":0.007407606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150585796854637,"score_gpt":0.2525541496847779,"score_spread":0.2374955699993142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}