{"id":"W4390199707","doi":"10.1002/alz.072107","title":"Synaptic proteasome is inhibited in Alzheimer’s disease models and is associated with memory impairment in mice","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Proteasome; Lactacystin; Synapse; Hippocampal formation; Synaptic plasticity; Neuroscience; Biology; Dendritic spine; Hippocampus; Cell biology; Proteasome inhibitor; In vivo; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002341396,0.001119256,0.0006112619,0.001211612,0.0003253257,0.000533132,0.0004442705,0.000701184,0.001843418],"category_scores_gemma":[0.0001542239,0.0004240297,0.0007734608,0.0003830995,0.0004278963,0.000373711,0.0002683295,0.0011957,0.0007457436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004790116,"about_ca_system_score_gemma":0.0002524757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005805687,"about_ca_topic_score_gemma":0.0006860616,"domain_scores_codex":[0.9997669,0.00001947092,0.00003458642,0.00007415202,0.00005221781,0.00005269606],"domain_scores_gemma":[0.9996679,0.00001740497,0.000168223,0.00002929534,0.00003114823,0.00008600581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006745055,0.0002291137,0.0008999761,0.00009142973,0.00006697868,0.0002495883,0.00002384509,0.00006071743,0.9953325,0.000138996,0.0001791002,0.002053265],"study_design_scores_gemma":[0.0001651806,0.002094006,0.03745498,0.00005753998,0.0002303839,0.002496601,0.00008463719,0.001436816,0.9515355,0.000384828,0.004039864,0.00001980557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878778,0.004488746,0.003473347,0.0002634484,0.00009142763,0.00005750162,0.001561627,0.0003008367,0.001885321],"genre_scores_gemma":[0.990693,0.002088321,0.001744145,0.0001650129,0.00002990571,0.0001372291,0.00151958,0.00007495435,0.003547816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001843418,"threshold_uncertainty_score":0.006166875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03918486685263515,"score_gpt":0.2987722132312099,"score_spread":0.2595873463785747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}