{"id":"W4390199978","doi":"10.1002/alz.079638","title":"Plasma biomarkers rates of change across the preclinical stage of Alzheimer’s disease: a longitudinal study","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biomarker; Medicine; Internal medicine; Confidence interval; Oncology; Cohort; Stage (stratigraphy); Disease; Logistic regression; Gastroenterology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002405527,0.0003776086,0.000379288,0.0006622331,0.0004805427,0.0007481542,0.0004343311,0.0007171807,0.0009332444],"category_scores_gemma":[0.003282897,0.0003117224,0.0004481417,0.0007206031,0.0003185667,0.0007642195,0.0004228603,0.0008377135,0.0003432175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002626852,"about_ca_system_score_gemma":0.0002801928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00239196,"about_ca_topic_score_gemma":0.001457903,"domain_scores_codex":[0.9990892,0.0002946894,0.00007132204,0.0003123,0.0001298671,0.0001026165],"domain_scores_gemma":[0.9975193,0.000409473,0.000842204,0.0004614541,0.0004839836,0.0002835614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001681734,0.0001688145,0.9919844,0.00001773905,0.0002458678,0.00007872524,0.0002429596,0.00007522604,0.001596424,0.00003763421,0.0001452507,0.003725165],"study_design_scores_gemma":[0.00002469948,0.0006529178,0.9976957,0.000005898961,0.0001081985,0.0002080153,0.0001259504,0.0003434238,0.0004560934,0.00006338245,0.0003034692,0.00001217722],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983888,0.0004263837,0.0004825857,0.00002216401,0.000008052742,0.00001630393,0.0003966162,0.000008686819,0.0002503532],"genre_scores_gemma":[0.9989654,0.00008483558,0.0002614065,0.00002012809,0.00001237538,0.00002106172,0.0003986507,0.000005231164,0.0002309583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002405527,"threshold_uncertainty_score":0.01272178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2075304010707864,"score_gpt":0.4449641028967123,"score_spread":0.2374337018259259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}