{"id":"W4390201101","doi":"10.1002/alz.078640","title":"Global platform trial design for tau (MAPT) mutation carriers","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"","keywords":"Placebo; Clinical trial; Medicine; Clinical study design; Observational study; Randomized controlled trial; Oncology; Sample size determination; Frontotemporal lobar degeneration; Internal medicine; Disease; Frontotemporal dementia; Pathology; Statistics; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06139643,0.002553657,0.004139152,0.0009480196,0.000413675,0.001331298,0.001383225,0.002516721,0.0149879],"category_scores_gemma":[0.06689508,0.0008937347,0.004958016,0.0006536738,0.001718781,0.002223684,0.002047993,0.002660031,0.0008240561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009668358,"about_ca_system_score_gemma":0.002329064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003081691,"about_ca_topic_score_gemma":0.0003576657,"domain_scores_codex":[0.9413293,0.0510388,0.002105762,0.003532869,0.001162992,0.0008303442],"domain_scores_gemma":[0.9577163,0.03099864,0.003334977,0.005457032,0.001464904,0.00102811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.7862437,0.003311467,0.007271603,0.006907611,0.01835832,0.0004651871,0.0004989385,0.05170675,0.004838661,0.0257127,0.005768842,0.08891619],"study_design_scores_gemma":[0.5222484,0.2030896,0.008422293,0.0008933422,0.01197756,0.000278536,0.0001532465,0.1571477,0.006318587,0.07256497,0.01665506,0.0002508248],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.501795,0.005635065,0.3200977,0.002243029,0.004156465,0.149057,0.004665461,0.002304362,0.01004589],"genre_scores_gemma":[0.6857182,0.0004566798,0.1151027,0.001246773,0.0002806424,0.1932214,0.0009083444,0.0001617318,0.002903427],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.06139643,"threshold_uncertainty_score":0.3246993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08324627563884879,"score_gpt":0.3587266431323821,"score_spread":0.2754803674935333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}