{"id":"W4390201542","doi":"10.1002/alz.075644","title":"Alzheimer’s Disease as an Innate Autoimmune Disease Regulated by Tryptophan and Arginine Metabolism","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Krembil Foundation","funders":"","keywords":"Innate immune system; Neuroscience; Mechanism (biology); Disease; Microglia; Computational biology; Biology; Immune system; Inflammation; Chemistry; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001881157,0.0002682705,0.0002165445,0.0001064303,0.000171194,0.000382776,0.0002416688,0.0002023381,0.001113963],"category_scores_gemma":[0.0000895503,0.00009809622,0.0003678239,0.0001080055,0.0003203896,0.0003370036,0.0001932036,0.0002823855,0.0001713856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002411102,"about_ca_system_score_gemma":0.0004000546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005941191,"about_ca_topic_score_gemma":0.0006547883,"domain_scores_codex":[0.9999396,0.00002166058,0.000003568208,0.00001355222,0.00001287419,0.000008798883],"domain_scores_gemma":[0.999963,0.00000944271,0.00001098134,0.000006286147,0.000005786057,0.000004429712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005703656,0.0002318393,0.01250229,0.001334596,0.0002036022,0.00106617,0.0001468364,0.06281559,0.8700286,0.03155332,0.0004739842,0.01907295],"study_design_scores_gemma":[0.0002841547,0.004372167,0.02520624,0.0002118868,0.0005325976,0.002596526,0.0005167856,0.2259745,0.6582215,0.04405553,0.03787245,0.0001557632],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959657,0.005990358,0.02494488,0.000236122,0.00006463959,0.00006446653,0.0001958822,0.000076086,0.008770576],"genre_scores_gemma":[0.9878902,0.003017157,0.00814288,0.0000392882,0.000008885957,0.00002226921,0.00009391607,0.000005723734,0.0007797994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001113963,"threshold_uncertainty_score":0.003726542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03546940870781051,"score_gpt":0.281899360823743,"score_spread":0.2464299521159325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}