{"id":"W4390201620","doi":"10.1002/alz.082650","title":"Interim phase 1 part A results for ALN‐APP, the first investigational RNAi therapeutic in development for Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Toronto Public Health","funders":"","keywords":"Tolerability; Medicine; Cohort; Pharmacodynamics; Internal medicine; Placebo; Clinical Dementia Rating; Clinical endpoint; Dementia; Amyloid precursor protein; Alzheimer's disease; Pharmacology; Oncology; Clinical trial; Pharmacokinetics; Disease; Adverse effect; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004789843,0.002227501,0.001603034,0.0005311222,0.001125229,0.002260601,0.001614086,0.003838966,0.03032379],"category_scores_gemma":[0.003518371,0.0009187795,0.001750642,0.0004642128,0.000534324,0.001101953,0.0006446375,0.003907757,0.007465659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001219243,"about_ca_system_score_gemma":0.00391965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001520631,"about_ca_topic_score_gemma":0.003822419,"domain_scores_codex":[0.9987143,0.0005358083,0.0000581585,0.0001663444,0.0002915167,0.0002338891],"domain_scores_gemma":[0.9972234,0.0004845793,0.0003741931,0.0002300276,0.0006674222,0.001020418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3736479,0.03114685,0.006489773,0.003717119,0.003496282,0.001016313,0.0004098781,0.002718215,0.07956161,0.003000587,0.3155847,0.1792106],"study_design_scores_gemma":[0.3709352,0.298252,0.02591768,0.0008145291,0.002383657,0.001323521,0.0001790706,0.002331174,0.02217006,0.003803291,0.2717398,0.0001500887],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4631725,0.04236784,0.02738802,0.01877762,0.01025231,0.1043872,0.1836288,0.003910135,0.1461157],"genre_scores_gemma":[0.5727738,0.01744474,0.03377526,0.02714223,0.002980491,0.08494473,0.1355818,0.001158724,0.1241981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03032379,"threshold_uncertainty_score":0.1014431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1276597687741252,"score_gpt":0.3780406896278195,"score_spread":0.2503809208536943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}