{"id":"W4390204634","doi":"10.5267/j.ccl.2023.11.005","title":"Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analogues","year":2023,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Foundation; National Research Foundation of Ukraine","keywords":"Chemistry; Ammonium; Biofilm; Antibacterial activity; Acetic acid; Staphylococcus aureus; Salt (chemistry); Escherichia coli; Strain (injury); Antimicrobial; Alkyl; Alkylation; Microbiology; Medicinal chemistry; Stereochemistry; Organic chemistry; Bacteria; Biochemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135172,0.0001474303,0.0002966145,0.00005641432,0.00004276009,0.00001772995,0.00007336235,0.00005885851,0.0001050043],"category_scores_gemma":[0.000133077,0.0001197283,0.00007380031,0.0001943028,0.0001819468,0.00005695651,0.00006435642,0.0001336724,0.000007098216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001600774,"about_ca_system_score_gemma":0.00002068394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006646986,"about_ca_topic_score_gemma":1.605562e-7,"domain_scores_codex":[0.9991869,0.00001390054,0.0001890635,0.0002735339,0.00012891,0.0002076714],"domain_scores_gemma":[0.9995509,0.00006520926,0.000087379,0.0002051964,0.00002409659,0.00006724506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005823268,0.00004262836,0.002634533,0.001035547,0.00004002649,0.00001259132,0.00003118343,1.123255e-7,0.9794682,0.000001467734,0.003231739,0.01344376],"study_design_scores_gemma":[0.000144819,0.00000331305,0.01069621,0.0003038778,0.00006963983,0.00002594417,0.00004569981,0.000007553685,0.9862044,0.000001975643,0.002370087,0.0001264222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960514,0.0004125115,8.979137e-7,0.003035458,0.0001775573,0.00009483969,0.0000854234,0.000072384,0.00006951898],"genre_scores_gemma":[0.998607,0.0008935331,0.00003958718,0.00003500191,0.0002984403,7.290784e-7,0.00007385218,0.00001333308,0.00003857008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01331734,"threshold_uncertainty_score":0.4882377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900361630495948,"score_gpt":0.2569226824541608,"score_spread":0.2379190661492014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}