{"id":"W4390204634","doi":"10.5267/j.ccl.2023.11.005","title":"Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analogues","year":2023,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research Foundation; National Research Foundation of Ukraine","keywords":"Chemistry; Ammonium; Biofilm; Antibacterial activity; Acetic acid; Staphylococcus aureus; Salt (chemistry); Escherichia coli; Strain (injury); Antimicrobial; Alkyl; Alkylation; Microbiology; Medicinal chemistry; Stereochemistry; Organic chemistry; Bacteria; Biochemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000135615,0.0003963091,0.0002728257,0.0002718831,0.0001337154,0.0002403899,0.0003125431,0.0003470398,0.00198551],"category_scores_gemma":[0.0001692695,0.0001497241,0.0002986763,0.0001332859,0.0001908157,0.0002496192,0.000220968,0.0004307525,0.0004927368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001698305,"about_ca_system_score_gemma":0.0001423915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002395706,"about_ca_topic_score_gemma":0.0003133167,"domain_scores_codex":[0.9999284,0.00001579183,0.00001211946,0.000015767,0.00001237377,0.0000155107],"domain_scores_gemma":[0.999908,0.00001251639,0.00002416751,0.00001051422,0.00001434161,0.00003044589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003170027,0.00007706664,0.0001787197,0.0002563306,0.00001892367,0.0003481072,0.00002827873,0.0002550159,0.9905166,0.000174684,0.00008113369,0.007748161],"study_design_scores_gemma":[0.0001737697,0.002461865,0.0040306,0.00003466824,0.00008634485,0.0008887126,0.00004595933,0.0003871575,0.977207,0.00009019871,0.01457074,0.00002297308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755408,0.01374579,0.00388217,0.0001842882,0.0001244265,0.0001361425,0.0004800056,0.00008347871,0.005822903],"genre_scores_gemma":[0.9839146,0.005870962,0.005637628,0.0002809235,0.00004816252,0.00008734057,0.0004952209,0.00001573685,0.003649424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00198551,"threshold_uncertainty_score":0.006642222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900361630495948,"score_gpt":0.2569226824541608,"score_spread":0.2379190661492014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}