{"id":"W4390225833","doi":"10.1002/pro.4885","title":"Structural and functional validation of a highly specific Smurf2 inhibitor","year":2023,"lang":"en","type":"article","venue":"Protein Science","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Regional Municipality of Waterloo; University of Waterloo; University of Toronto; University of Guelph","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Computational biology; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003077252,0.0004652725,0.0003754327,0.0002026263,0.0002228613,0.00024776,0.0004670898,0.0003875838,0.000727359],"category_scores_gemma":[0.0001658962,0.0001339428,0.0002941366,0.0001932633,0.0001795081,0.0001598084,0.000139371,0.0004111971,0.0002912562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004688831,"about_ca_system_score_gemma":0.000302064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009757325,"about_ca_topic_score_gemma":0.001255556,"domain_scores_codex":[0.9997876,0.00004122126,0.00001687389,0.00003211258,0.0000824339,0.00003963325],"domain_scores_gemma":[0.9999071,0.00001074244,0.00002464613,0.000009279674,0.00002591379,0.00002232418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001096526,0.00009941624,0.0001332818,0.00003363796,0.00001929151,0.00006274296,0.000007544756,0.0004644572,0.9971631,0.0000890188,0.0000730562,0.001744825],"study_design_scores_gemma":[0.00001898745,0.0003551789,0.0005123456,0.000001658526,0.00001709086,0.0001811941,0.000004683338,0.001076481,0.9957712,0.000008152501,0.002049299,0.000003674866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891546,0.002750811,0.005708171,0.00009353647,0.00002521623,0.00008944723,0.0005169157,0.00007733818,0.001583972],"genre_scores_gemma":[0.9910444,0.0009759368,0.005127307,0.00004464286,0.00000765349,0.00004270582,0.001211527,0.00002254464,0.001523345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009757325,"threshold_uncertainty_score":0.003401995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02668907013931612,"score_gpt":0.2503233136710333,"score_spread":0.2236342435317172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}