{"id":"W4390226028","doi":"10.1038/s41375-023-02117-2","title":"Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia","year":2023,"lang":"en","type":"article","venue":"Leukemia","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"U.S. Food and Drug Administration; National Cancer Institute; National Institutes of Health; Universität Zürich; Mochida Memorial Foundation for Medical and Pharmaceutical Research; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas; Boettcher Foundation; Uehara Memorial Foundation","keywords":"GPX4; Lipid peroxidation; Mitochondrion; Apoptosis; Programmed cell death; Myeloid leukemia; Cancer research; Biology; Cell biology; Gene knockdown; Chemistry; Oxidative stress; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002060451,0.000177495,0.0002601346,0.0001431961,0.000189782,0.0002724568,0.0002195262,0.0002579604,0.001797909],"category_scores_gemma":[0.0002018887,0.00007304341,0.0001446491,0.000137146,0.0002023332,0.0001761418,0.0001931108,0.0003977578,0.0001999744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000499263,"about_ca_system_score_gemma":0.0002122615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006026521,"about_ca_topic_score_gemma":0.0008528824,"domain_scores_codex":[0.999893,0.00003127193,0.000007994554,0.00001224646,0.0000208314,0.00003462256],"domain_scores_gemma":[0.9999483,0.000007602152,0.00001996298,0.000004786777,0.000009046532,0.00001042789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003742211,0.0001691477,0.001633557,0.0001449346,0.00003587267,0.000133177,0.00004688111,0.0002469464,0.9841584,0.00051104,0.0005589691,0.00861881],"study_design_scores_gemma":[0.00042773,0.002161134,0.02510391,0.00002973313,0.00008422504,0.0006178963,0.0002009347,0.003492783,0.9579192,0.0005012157,0.009447171,0.00001401243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950783,0.002516388,0.0007364895,0.0003041706,0.00004638058,0.00001977895,0.000129745,0.00004438702,0.001124348],"genre_scores_gemma":[0.9981711,0.0005375241,0.0002835852,0.00003765378,0.000007640884,0.00001127214,0.00008851615,0.000003506602,0.0008592855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001797909,"threshold_uncertainty_score":0.006014645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01755796360448915,"score_gpt":0.2651483724861873,"score_spread":0.2475904088816981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}