{"id":"W4390232280","doi":"10.3390/ph17010037","title":"An In Silico Investigation of the Molecular Interactions between Volatile Anesthetics and Actin","year":2023,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Halothane; Desflurane; Anesthetic; Isoflurane; Chemistry; Sevoflurane; In silico; Volatile anesthetic; Biophysics; Medicine; Pharmacology; Biochemistry; Anesthesia; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002807766,0.00007276011,0.0001067659,0.0001159532,0.00007437336,0.00002585406,0.0002145068,0.00003129404,0.00002635285],"category_scores_gemma":[0.0003330036,0.0000570943,0.00002717553,0.0007315475,0.000244627,0.0001370071,0.00007204604,0.0002535328,0.00002239287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001073016,"about_ca_system_score_gemma":0.00002914213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007521529,"about_ca_topic_score_gemma":0.000001812463,"domain_scores_codex":[0.998746,0.0004342954,0.0001727317,0.000208479,0.0002448838,0.0001936591],"domain_scores_gemma":[0.9991017,0.0005439224,0.00004154981,0.0001906632,0.00001651641,0.0001056774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008882598,0.00001832977,0.106371,0.00001396736,7.897474e-7,0.00001078674,0.0002370174,0.00002530029,0.8919308,0.0004550397,0.00001781982,0.0009102626],"study_design_scores_gemma":[0.0001480071,0.00002788545,0.07108606,0.00001352878,0.00000591373,0.00001240399,0.00002901023,0.008057685,0.9188798,0.001042541,0.0006438185,0.00005332289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965582,0.000005344258,0.00001012668,0.002898467,0.00002244072,0.0003101892,0.000004826672,0.00003905976,0.0001512874],"genre_scores_gemma":[0.9993695,0.00002284478,0.00001139523,0.0005014285,0.0000141294,0.00002053498,9.933918e-7,0.00001158027,0.00004756366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03528491,"threshold_uncertainty_score":0.2328238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1524309795504656,"score_gpt":0.4272865479941428,"score_spread":0.2748555684436773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}