{"id":"W4390233603","doi":"10.7150/thno.85437","title":"Combined BET and MEK Inhibition synergistically suppresses melanoma by targeting YAP1","year":2023,"lang":"en","type":"article","venue":"Theranostics","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"China Postdoctoral Science Foundation; Central South University; National Natural Science Foundation of China; National Key Research and Development Program of China; Yale University","keywords":"YAP1; Trametinib; MEK inhibitor; Melanoma; Cancer research; Hippo signaling pathway; Downregulation and upregulation; Biology; Chemistry; MAPK/ERK pathway; Signal transduction; Cell biology; Transcription factor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008762533,0.000422527,0.0003254746,0.0002925414,0.000125882,0.0002423298,0.0001668826,0.000172389,0.001408076],"category_scores_gemma":[0.00005866909,0.0001515081,0.0002472333,0.000125307,0.0001271053,0.0001905406,0.000177776,0.0005523591,0.0002949318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002147331,"about_ca_system_score_gemma":0.0001690167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003421414,"about_ca_topic_score_gemma":0.001722395,"domain_scores_codex":[0.999916,0.000009735429,0.000006016225,0.00001231788,0.00002920733,0.00002678184],"domain_scores_gemma":[0.9999737,0.000003673611,0.000005619127,0.000002786529,0.000002711987,0.00001152323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002464008,0.00008335183,0.000273425,0.00003945019,0.00001582376,0.00005593171,0.000007958613,0.000138313,0.995861,0.0001316137,0.0001135506,0.003033163],"study_design_scores_gemma":[0.00007251826,0.001226424,0.004585042,0.000004968354,0.00004570256,0.0005512563,0.00001996875,0.001473767,0.9873337,0.00006660581,0.004612648,0.000007550195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949186,0.001330265,0.001106813,0.0001230835,0.00004563608,0.00003543792,0.0003350755,0.00006866394,0.002036331],"genre_scores_gemma":[0.9949115,0.0008535685,0.00117733,0.00003928683,0.00001021124,0.00003571209,0.0003848854,0.00001152154,0.002576104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001408076,"threshold_uncertainty_score":0.004710436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006042556253851118,"score_gpt":0.2220941309684641,"score_spread":0.216051574714613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}