{"id":"W4390236172","doi":"10.3390/ijms25010299","title":"RanBP2/Nup358 Mediates Sumoylation of STAT1 and Antagonizes Interferon-α-Mediated Antiviral Innate Immunity","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Fujian Medical University; Natural Science Foundation of Fujian Province","keywords":"Innate immune system; Interferon; Biology; Cell biology; Intrinsic immunity; Signal transduction; STAT1; SUMO protein; Janus kinase; Immune system; Virology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861501,0.000414157,0.0003094808,0.0001704694,0.0002044703,0.0002444916,0.0002227249,0.0002504297,0.001286686],"category_scores_gemma":[0.00009539072,0.0001309471,0.000262986,0.0001046887,0.0002590535,0.0002085629,0.0001973411,0.0004471132,0.0004624907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002074562,"about_ca_system_score_gemma":0.0001868175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003489993,"about_ca_topic_score_gemma":0.0006605192,"domain_scores_codex":[0.9998341,0.00003562937,0.00001388168,0.00002964005,0.00004076374,0.00004601848],"domain_scores_gemma":[0.9999442,0.000007170714,0.00001527116,0.000007712284,0.000006215716,0.00001947452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001443017,0.000018104,0.0001171134,0.00003121625,0.000005357529,0.0000503009,0.000006174198,0.00005582822,0.9988678,0.00007869656,0.00003185374,0.000593338],"study_design_scores_gemma":[0.00002605551,0.0001736555,0.003432116,0.000004472075,0.00001119872,0.0003442647,0.00001741805,0.001454861,0.9925724,0.00004323517,0.00191638,0.00000400802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912935,0.00286373,0.003105844,0.0001077901,0.00005253439,0.00002058574,0.0001897018,0.00009567584,0.00227052],"genre_scores_gemma":[0.9966377,0.0006326642,0.0008426277,0.00003530431,0.000009760264,0.00001760516,0.0002952905,0.00001157004,0.001517395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001286686,"threshold_uncertainty_score":0.004304409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01511667516972173,"score_gpt":0.289909332531847,"score_spread":0.2747926573621253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}