{"id":"W4390236634","doi":"10.1038/s41423-023-01116-8","title":"In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms","year":2023,"lang":"en","type":"review","venue":"Cellular and Molecular Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Rosetrees Trust; Research Councils UK","keywords":"Coronavirus; Pandemic; Virology; Coronaviridae; Transmission (telecommunications); Immunity; Blueprint; Biology; Coronavirus disease 2019 (COVID-19); Disease; Immune system; Immunology; Medicine; Infectious disease (medical specialty); Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007737438,0.0006561909,0.001037328,0.001254786,0.0002045463,0.0009043778,0.0006954289,0.001530313,0.002507631],"category_scores_gemma":[0.0007227971,0.0002436973,0.0004810957,0.0009865382,0.0004398161,0.0019331,0.0005428406,0.002511454,0.001579619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005856563,"about_ca_system_score_gemma":0.0008878222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004837782,"about_ca_topic_score_gemma":0.0008078387,"domain_scores_codex":[0.9998295,0.00003606887,0.00001781072,0.00003124843,0.00006278529,0.00002255794],"domain_scores_gemma":[0.9997386,0.0001330728,0.00002873031,0.000008013845,0.00006568924,0.00002590666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001115614,0.0001366203,0.0001673637,0.01639184,0.0001040038,0.0002190297,0.00006881724,0.0008019173,0.006829783,0.0113015,0.03541412,0.9284534],"study_design_scores_gemma":[0.00002499589,0.0001938069,0.0003428521,0.002832149,0.00007960552,0.000673632,0.00004924573,0.0001424645,0.0008954959,0.003702689,0.991048,0.00001500405],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001826225,0.9969681,0.0003397299,0.0009778928,0.0004123171,0.000008460612,0.00001740276,0.00001124603,0.00108229],"genre_scores_gemma":[0.0007511786,0.9972321,0.0004841071,0.0006645399,0.0002147068,0.00001399071,0.00003222988,0.000001807473,0.0006052542],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002507631,"threshold_uncertainty_score":0.008388877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1154121500800257,"score_gpt":0.3710509131870463,"score_spread":0.2556387631070206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}