{"id":"W4390236634","doi":"10.1038/s41423-023-01116-8","title":"In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms","year":2023,"lang":"en","type":"review","venue":"Cellular and Molecular Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Rosetrees Trust; Research Councils UK","keywords":"Coronavirus; Pandemic; Virology; Coronaviridae; Transmission (telecommunications); Immunity; Blueprint; Biology; Coronavirus disease 2019 (COVID-19); Disease; Immune system; Immunology; Medicine; Infectious disease (medical specialty); Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001005492,0.0004722704,0.002038108,0.000884906,0.00006578218,0.00003424361,0.0002497146,0.0007143096,0.00001430955],"category_scores_gemma":[0.0001531163,0.0004129684,0.0002650477,0.0006792112,0.00008255748,0.00006780525,0.0003651428,0.0008110221,0.00004268039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001020471,"about_ca_system_score_gemma":0.0005113324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003113766,"about_ca_topic_score_gemma":0.00001084911,"domain_scores_codex":[0.9968845,0.0006593708,0.0009007577,0.0007125695,0.0002846127,0.0005581644],"domain_scores_gemma":[0.9987921,0.0001998915,0.0001804315,0.0006570422,0.0001256261,0.0000448939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001657388,0.0001117969,0.000003351697,0.0054278,0.0005165086,0.00109112,0.00008001864,2.442547e-7,0.7216943,0.0009148321,0.00001559945,0.2699787],"study_design_scores_gemma":[0.005968126,0.002366035,0.00003361831,0.005603211,0.001687985,0.001168305,0.0001345409,0.0006307125,0.6431355,0.001067042,0.3371989,0.001006119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008370524,0.9818668,0.007642547,0.00006109928,0.0001587375,0.001820826,0.000006839098,0.00003769742,0.00003491531],"genre_scores_gemma":[0.001985306,0.9961312,0.0005870416,0.0006881029,0.00005895225,0.0002419367,0.00009647933,0.0001348168,0.00007615975],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3371832,"threshold_uncertainty_score":0.9998322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1154121500800257,"score_gpt":0.3710509131870463,"score_spread":0.2556387631070206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}