{"id":"W4390237156","doi":"10.1093/neuonc/noad227","title":"Consensus framework for conducting phase I/II clinical trials for children, adolescents, and young adults with pediatric low-grade glioma: Guidelines established by the International Pediatric Low-Grade Glioma Coalition Clinical Trial Working Group","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Brain Tumour Charity; Pediatric Brain Tumor Foundation","keywords":"Clinical trial; Medicine; Clinical endpoint; Pace; Quality of life (healthcare); Glioma; Dosing; Clinical study design; Intensive care medicine; Pediatrics; Internal medicine; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4148751,0.003984495,0.01115993,0.006629813,0.00551412,0.01704461,0.0216608,0.02402123,0.004914809],"category_scores_gemma":[0.271468,0.003944028,0.02103119,0.009638662,0.008234263,0.006700102,0.00838853,0.03319068,0.01051578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009064579,"about_ca_system_score_gemma":0.06901133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007238662,"about_ca_topic_score_gemma":0.01026114,"domain_scores_codex":[0.6146458,0.2800999,0.06603734,0.007618099,0.0241705,0.00742842],"domain_scores_gemma":[0.6546218,0.1356214,0.04420958,0.02763721,0.1150854,0.02282462],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00706015,0.0007780791,0.002580314,0.04317535,0.004090519,0.0009566983,0.002833678,0.0064917,0.003929185,0.05169141,0.5592253,0.3171875],"study_design_scores_gemma":[0.01126767,0.001698491,0.004966113,0.07145317,0.004120959,0.0009983764,0.0009197071,0.004799964,0.003020718,0.06049578,0.8357806,0.000478424],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.003393861,0.1560528,0.2802514,0.2971712,0.03057572,0.165309,0.01054224,0.003143715,0.0535601],"genre_scores_gemma":[0.01983604,0.04328687,0.6152374,0.1087291,0.008436834,0.1847919,0.008838746,0.001317167,0.009525993],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.585125,"threshold_uncertainty_score":0.7215632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2008857217994826,"score_gpt":0.4618926606091563,"score_spread":0.2610069388096737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}