{"id":"W4390245551","doi":"10.1016/j.crtox.2023.100147","title":"Ethylene dimethanesulfonate effects on gene promoter activities related to the endocrine function of immortalized Leydig cell lines R2C and MA-10","year":2023,"lang":"en","type":"article","venue":"Current Research in Toxicology","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Universidade Estadual Paulista; Fundação de Amparo à Pesquisa do Estado de São Paulo; McGill University; Canadian Institutes of Health Research; Washington State University","keywords":"Endocrine system; Ethylene; Gene; Leydig cell; Function (biology); Biology; Promoter; Cell biology; Genetics; Endocrinology; Gene expression; Hormone; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008678422,0.0001536271,0.000210093,0.0002817545,0.00008741324,0.00001401753,0.0001784872,0.000136633,0.00004028802],"category_scores_gemma":[0.0001302412,0.0001129127,0.0000628659,0.0004523932,0.000152251,0.000004635866,0.0001839394,0.0003386517,0.00003479425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000016222,"about_ca_system_score_gemma":0.00006851853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002437585,"about_ca_topic_score_gemma":0.00005555706,"domain_scores_codex":[0.9980863,0.0005798612,0.0002401201,0.0003917501,0.0002311708,0.0004708006],"domain_scores_gemma":[0.9992516,0.0002532646,0.00003688507,0.0002977819,0.00006998565,0.00009050264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008855209,0.0001636321,0.0005827392,0.0001629833,0.00003248705,0.000021345,0.0001449242,0.0001009514,0.9642944,0.0001008019,0.001496244,0.03201396],"study_design_scores_gemma":[0.00156903,0.002655501,0.01098907,0.00005267161,0.00001351234,0.00000924889,0.00004349218,0.00007632909,0.9595917,0.0003101775,0.02454822,0.0001410205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946061,0.002560608,0.000020737,0.00143757,0.0004696937,0.0006993227,0.00002517707,0.00001432887,0.0001664417],"genre_scores_gemma":[0.9960988,0.002148304,0.00001378294,0.00004881842,0.0001205375,0.000215967,0.0001217753,0.00002132059,0.001210709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03187294,"threshold_uncertainty_score":0.4604445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04263664648161952,"score_gpt":0.3644029652773337,"score_spread":0.3217663187957142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}