{"id":"W4390246012","doi":"10.1016/j.ejcb.2023.151382","title":"Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes","year":2023,"lang":"en","type":"article","venue":"European Journal of Cell Biology","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Phagolysosome; Lysis; Lysosome; Cytolysis; Cell biology; Membrane; Endosome; Exocytosis; Biochemistry; Phagosome; Cholesterol; Chemistry; Endocytosis; Biophysics; Biology; Phagocytosis; Enzyme; Cell; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002827513,0.00009648666,0.0002676294,0.0003243599,0.00004584139,0.00001223743,0.0002298321,0.00004022884,0.00008058496],"category_scores_gemma":[0.0003036024,0.00006349514,0.000124835,0.0005096586,0.00009028037,0.00009327242,0.0000432577,0.0004190519,0.00006808015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003478409,"about_ca_system_score_gemma":0.00004073155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009001351,"about_ca_topic_score_gemma":0.000001302859,"domain_scores_codex":[0.9974059,0.00146439,0.0005435202,0.0001353901,0.0002046661,0.000246124],"domain_scores_gemma":[0.9990262,0.0002205225,0.0003852499,0.000166166,0.0001430597,0.00005883856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005742878,0.000265601,0.03441569,0.00008208559,0.00008537378,0.0004417702,0.001903823,0.00006108878,0.9351281,0.000006899446,0.006372416,0.02066291],"study_design_scores_gemma":[0.01472305,0.007920014,0.5903803,0.0004665397,0.0002766451,0.0007500454,0.008725679,0.003563675,0.2066017,0.0001313217,0.1659729,0.0004881271],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908118,0.0007906318,0.0003669647,0.001769156,0.00009596054,0.0001288197,0.000007160905,0.000009160151,0.006020353],"genre_scores_gemma":[0.9980202,0.0008636941,0.0001982974,0.0003336313,0.000135743,0.000001090106,0.00001600056,0.00001816302,0.000413149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7285264,"threshold_uncertainty_score":0.2589257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03136692879740081,"score_gpt":0.308268102888464,"score_spread":0.2769011740910632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}