{"id":"W4390260558","doi":"10.1016/j.jns.2023.121583","title":"Repurposing mTOR inhibitors to treat epilepsy due to tuberous sclerosis complex: A narrative review","year":2023,"lang":"en","type":"review","venue":"Journal of the Neurological Sciences","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Children's Hospital; McGill University Health Centre","funders":"","keywords":"Tuberous sclerosis; Repurposing; Epilepsy; PI3K/AKT/mTOR pathway; Narrative review; Discovery and development of mTOR inhibitors; Medicine; Drug repositioning; Neuroscience; Pharmacology; Intensive care medicine; Psychology; Pathology; Biology; Psychiatry; Genetics; Drug; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004084866,0.0005743943,0.003558468,0.0005700447,0.0006826298,0.0002064502,0.00230219,0.0002269318,0.0001903332],"category_scores_gemma":[0.006727717,0.0002615285,0.001532294,0.004918396,0.0006429267,0.0001311089,0.001141904,0.001594623,0.000231274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002641464,"about_ca_system_score_gemma":0.0006070394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002397489,"about_ca_topic_score_gemma":0.00001257204,"domain_scores_codex":[0.9920986,0.001789098,0.001967782,0.0008410172,0.002412419,0.0008910876],"domain_scores_gemma":[0.9953519,0.001586007,0.001081079,0.0006767724,0.0004080823,0.000896191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001427861,0.0003232057,0.0001951549,0.00935117,0.0001351922,0.0006094775,0.000306054,0.0000356585,0.000212862,0.00003324775,0.1325727,0.8560826],"study_design_scores_gemma":[0.0003503461,0.008808323,0.002849881,0.1252542,0.001118198,0.006988219,0.00005630792,0.00000969476,0.00001375922,0.00009022115,0.8539683,0.0004925629],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01051865,0.9605402,0.000005501302,0.02453782,0.0009090069,0.003119946,0.00002025716,0.00006124021,0.0002873302],"genre_scores_gemma":[0.0002942939,0.9895679,0.0007803583,0.00810925,0.0008221267,0.0000848533,0.000001269927,0.0000488336,0.0002911487],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.85559,"threshold_uncertainty_score":0.9999837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3031110136844922,"score_gpt":0.4266686662674402,"score_spread":0.123557652582948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}