{"id":"W4390261892","doi":"10.1016/j.jns.2023.121718","title":"Phase 3, open-label, multicenter safety study of oral edaravone in patients with amyotrophic lateral sclerosis (MT-1186-A01): 48-week results","year":2023,"lang":"en","type":"article","venue":"Journal of the Neurological Sciences","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Amyotrophic lateral sclerosis; Edaravone; Medicine; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00218928,0.002540274,0.003566879,0.0004895962,0.0007684156,0.001443122,0.001272309,0.002345858,0.004907752],"category_scores_gemma":[0.001457815,0.0008215075,0.002580208,0.0004278051,0.001506699,0.0014696,0.0003640316,0.00394371,0.001662175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008464141,"about_ca_system_score_gemma":0.001794488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001276898,"about_ca_topic_score_gemma":0.002225348,"domain_scores_codex":[0.9993269,0.0002863233,0.00003286629,0.0001176277,0.00007458233,0.000161723],"domain_scores_gemma":[0.9985983,0.0003008729,0.0002366944,0.0001831522,0.0001549612,0.0005259886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8979514,0.03548975,0.002236881,0.0005441059,0.001634329,0.0001769879,0.000252404,0.00116944,0.02053134,0.0001626487,0.003113662,0.03673702],"study_design_scores_gemma":[0.7200174,0.2625619,0.01089851,0.00003523644,0.0007036353,0.0001897632,0.00009753043,0.0007873048,0.002424592,0.0002720274,0.001950788,0.00006117587],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885373,0.002639146,0.001424372,0.0005320607,0.0002410369,0.002162687,0.002546025,0.0002577082,0.001659642],"genre_scores_gemma":[0.9819983,0.001796034,0.00228903,0.00152896,0.0003766913,0.003635684,0.003782075,0.0001147882,0.004478379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004907752,"threshold_uncertainty_score":0.0164181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.132844724542709,"score_gpt":0.3661294958712727,"score_spread":0.2332847713285637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}