{"id":"W4390263338","doi":"10.1097/tp.0000000000004877","title":"Distinct Molecular Processes Mediate Donor-derived Cell-free DNA Release From Kidney Transplants in Different Disease States","year":2023,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"Natera","keywords":"DNA; Disease; Cell-free fetal DNA; Cell; Kidney; Medicine; Biology; Cell biology; Cancer research; Computational biology; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006668354,0.0003645443,0.0004197326,0.0002689394,0.00007612305,0.00003492676,0.0001564632,0.0000886602,0.0001372673],"category_scores_gemma":[0.00003814685,0.0002890493,0.0001300654,0.0004707936,0.00004958628,0.0001683682,0.000006611574,0.0001591542,0.0001136358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005676759,"about_ca_system_score_gemma":0.0001558928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002451303,"about_ca_topic_score_gemma":0.000211372,"domain_scores_codex":[0.9980037,0.00008523301,0.0004889839,0.0005037063,0.0005079554,0.0004104215],"domain_scores_gemma":[0.9987602,0.0002367041,0.00009303129,0.0003133169,0.0000570135,0.0005397494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0138345,0.00183494,0.8202837,0.01695953,0.0005615735,0.01865548,0.009919461,0.0008714313,0.1155372,0.00006346322,0.0002201931,0.001258523],"study_design_scores_gemma":[0.01405854,0.0001421321,0.8814869,0.001707536,0.0009301117,0.0000132205,0.0001014637,0.0006182239,0.09954091,0.001005238,0.00002904565,0.0003666623],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907194,0.0001721249,0.001435575,0.001236621,0.0001350666,0.000734309,0.005096295,0.0002525612,0.0002180163],"genre_scores_gemma":[0.9704044,0.004908469,0.0001591778,0.0003195997,0.00004858688,0.0001545742,0.02381581,0.00005422284,0.0001351803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06120319,"threshold_uncertainty_score":0.9999562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01398242268221476,"score_gpt":0.2581622906220438,"score_spread":0.244179867939829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}