{"id":"W4390263801","doi":"10.1002/anie.202314450","title":"Selective Hemin Binding by a Non‐G‐quadruplex Aptamer with Higher Affinity and Better Peroxidase‐like Activity","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Xiamen University; State Key Laboratory of Marine Environmental Science; China Scholarship Council; University of Waterloo","keywords":"Aptamer; Hemin; G-quadruplex; Peroxidase; Chemistry; Combinatorial chemistry; Biochemistry; Molecular biology; Enzyme; Heme; Biology; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001912735,0.0003356814,0.0002679903,0.0002104466,0.0001511357,0.0002300417,0.0002241711,0.0004398063,0.001296754],"category_scores_gemma":[0.0001805675,0.0001483273,0.0001652034,0.0001278021,0.0001681572,0.0001854435,0.0001620107,0.0004156012,0.0004600368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000272626,"about_ca_system_score_gemma":0.0001155812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002209271,"about_ca_topic_score_gemma":0.0003274647,"domain_scores_codex":[0.9997737,0.00003645342,0.00001676913,0.00008139255,0.00005367707,0.00003799217],"domain_scores_gemma":[0.9998639,0.00003426278,0.00003010668,0.00001215091,0.0000290615,0.00003041634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001704047,0.00001163008,0.0000449414,0.00001087885,0.00000139953,0.00001206109,0.000006276159,0.0000389856,0.999079,0.00002721018,0.0000263142,0.0007242771],"study_design_scores_gemma":[0.000006762227,0.00007938268,0.0008377428,9.900422e-7,0.000003422397,0.0001317584,0.000003362147,0.001086065,0.997329,0.00001313713,0.0005047612,0.000003584726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886678,0.0006628981,0.008953,0.0001196243,0.00003601107,0.00003267903,0.00009212847,0.0002058101,0.001229938],"genre_scores_gemma":[0.9902396,0.0001200641,0.00699187,0.0001134343,0.00001276534,0.00001904272,0.0001110404,0.00003043143,0.002361688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296754,"threshold_uncertainty_score":0.004338086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009361438952616626,"score_gpt":0.2610144235415817,"score_spread":0.2516529845889651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}