{"id":"W4390263801","doi":"10.1002/anie.202314450","title":"Selective Hemin Binding by a Non‐G‐quadruplex Aptamer with Higher Affinity and Better Peroxidase‐like Activity","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Xiamen University; State Key Laboratory of Marine Environmental Science; China Scholarship Council; University of Waterloo","keywords":"Aptamer; Hemin; G-quadruplex; Peroxidase; Chemistry; Combinatorial chemistry; Biochemistry; Molecular biology; Enzyme; Heme; Biology; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050834,0.0001624187,0.0001202366,0.00007825228,0.00008889265,0.0000395579,0.00008742313,0.0001345698,0.00001483579],"category_scores_gemma":[0.00002425502,0.000139893,0.00005456056,0.0001689266,0.0001007757,0.00002216481,0.00007185462,0.000121248,0.000006547332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004271964,"about_ca_system_score_gemma":0.00001775829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000197884,"about_ca_topic_score_gemma":0.00001642118,"domain_scores_codex":[0.9991184,0.00001424266,0.0001075675,0.0003805346,0.000203098,0.0001761213],"domain_scores_gemma":[0.9995678,0.00002022425,0.0000961105,0.0001267778,0.0001338831,0.00005520073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009296858,0.00004261639,0.0008554708,0.000007510604,0.0001011137,0.000003786897,0.00001552266,5.730258e-7,0.9490512,0.000002002003,0.04900312,0.0008241168],"study_design_scores_gemma":[0.0003310228,0.0001011738,0.002048409,0.00002525787,0.00002165493,0.000008056684,0.00002859248,0.00003194897,0.9804004,0.00004345652,0.01676784,0.0001922088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957052,0.00001648747,0.00152541,0.001016998,0.0001340536,0.00009060558,0.0001631669,0.00007457355,0.001273442],"genre_scores_gemma":[0.9941195,0.0001039954,0.0005451959,0.000386641,0.0005113077,0.00003161374,0.001374096,0.00002035007,0.002907283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03223528,"threshold_uncertainty_score":0.5704671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009361438952616626,"score_gpt":0.2610144235415817,"score_spread":0.2516529845889651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}