{"id":"W4390263839","doi":"10.1002/ange.202314450","title":"Selective Hemin Binding by a Non‐G‐quadruplex Aptamer with Higher Affinity and Better Peroxidase‐like Activity","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Xiamen University; State Key Laboratory of Marine Environmental Science; China Scholarship Council; University of Waterloo","keywords":"Aptamer; Hemin; Isothermal titration calorimetry; G-quadruplex; Chemistry; Stacking; Combinatorial chemistry; Heme; Stereochemistry; Biochemistry; DNA; Enzyme; Organic chemistry; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000200269,0.0003437867,0.000271472,0.000217968,0.0001612213,0.000231597,0.0002295293,0.0004572534,0.001351226],"category_scores_gemma":[0.0001907095,0.0001527233,0.000164599,0.0001276302,0.0001777439,0.0001911375,0.0001655325,0.0004328134,0.0004634934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002884749,"about_ca_system_score_gemma":0.0001176528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002279038,"about_ca_topic_score_gemma":0.0003485573,"domain_scores_codex":[0.9997625,0.00003916417,0.00001757879,0.00008438648,0.00005635593,0.0000400279],"domain_scores_gemma":[0.9998566,0.00003544661,0.00003086374,0.00001303712,0.00003060235,0.0000333934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001788929,0.00001239137,0.00004514393,0.00001088327,0.000001507012,0.00001250974,0.000006572673,0.00004107341,0.9991026,0.00002952741,0.00002727351,0.0006926631],"study_design_scores_gemma":[0.000007098874,0.00007863049,0.0008091243,9.753253e-7,0.000003260626,0.0001302805,0.000003394002,0.001174682,0.9972757,0.00001356705,0.0004996774,0.000003656495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890477,0.0005936499,0.00871905,0.0001211829,0.00003473665,0.00003160643,0.00008910333,0.0002079958,0.00115502],"genre_scores_gemma":[0.9908093,0.0001030753,0.006686429,0.000111323,0.00001213286,0.00001847108,0.0000970643,0.00003062997,0.002131475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351226,"threshold_uncertainty_score":0.004520357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045566229085807,"score_gpt":0.2514041918588352,"score_spread":0.2409485295679772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}