{"id":"W4390314734","doi":"10.1158/1940-6207.capr-23-0256","title":"Breast Cancer Polygenic-Risk Score Influence on Risk-Reducing Endocrine Therapy Use: Genetic Risk Estimate (GENRE) Trial 1-Year and 2-Year Follow-Up","year":2023,"lang":"en","type":"article","venue":"Cancer Prevention Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Breast cancer; Medicine; Cancer; Confidence interval; Internal medicine; Adverse effect; Quality of life (healthcare); Polygenic risk score; Risk assessment; Randomized controlled trial; Oncology; Demography; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001151488,0.0002760019,0.0002472527,0.0002846119,0.0005742248,0.0001739114,0.0003831483,0.0002328157,0.0003762796],"category_scores_gemma":[0.000410409,0.0002672954,0.0001613271,0.0007860961,0.0002876241,0.00002818606,0.0002774982,0.0007309121,0.00008186328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002688782,"about_ca_system_score_gemma":0.001029008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004539973,"about_ca_topic_score_gemma":0.001171282,"domain_scores_codex":[0.9964554,0.000791757,0.0004085134,0.0009623048,0.0006579511,0.000724024],"domain_scores_gemma":[0.9981838,0.0001273624,0.0002457573,0.0007564854,0.0004827386,0.0002037975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02874401,0.000254666,0.4381563,0.0001432766,0.001177345,0.00001865407,0.0006880918,0.03653086,0.0806972,0.00004593726,0.02394137,0.3896023],"study_design_scores_gemma":[0.04050252,0.001760967,0.8823904,0.000348545,0.0001749932,0.00002267017,0.0003183355,0.001488793,0.05797656,0.0007941335,0.01332614,0.0008959629],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938598,0.002857168,0.0001264537,0.0002672362,0.0006521619,0.001253327,0.0008761023,0.00005650557,0.0000512548],"genre_scores_gemma":[0.9414654,0.05295748,0.0003869042,0.00003612541,0.0007901473,0.001198965,0.00007987348,0.00008596721,0.00299917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4442341,"threshold_uncertainty_score":0.9999779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05729531377564007,"score_gpt":0.4073186287152781,"score_spread":0.3500233149396381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}