{"id":"W4390325416","doi":"10.1080/19336950.2023.2297621","title":"Reducing agents facilitate membrane patch seal integrity and longevity","year":2023,"lang":"en","type":"article","venue":"Channels","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Patch clamp; Seal (emblem); Ohm; Ion channel; Electrophysiology; Voltage clamp; Heterologous; Biophysics; Chemistry; Cell biology; Biology; Neuroscience; Biochemistry; Electrical engineering; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005712953,0.0005642524,0.0005295236,0.0003063497,0.0002867223,0.0005314228,0.0003986523,0.0004952012,0.001846616],"category_scores_gemma":[0.001150979,0.0002260118,0.0003014064,0.0002099584,0.0003316816,0.0006189278,0.0003864836,0.0008480808,0.0005388876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001760609,"about_ca_system_score_gemma":0.0002278475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004554817,"about_ca_topic_score_gemma":0.0009021698,"domain_scores_codex":[0.9996006,0.00007071766,0.00007036059,0.000115552,0.00009319397,0.00004971592],"domain_scores_gemma":[0.9993041,0.0001895261,0.0001865643,0.0001096814,0.000167153,0.00004298526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002633646,0.000008340255,0.00008800212,0.00008238958,0.000004859625,0.00004689728,0.0000320698,0.00003397116,0.9972699,0.0001132097,0.00006837075,0.002225492],"study_design_scores_gemma":[0.000005190051,0.000101471,0.001844671,0.00001694807,0.00002340764,0.0002116767,0.00002764235,0.0003572422,0.9908667,0.0001140465,0.006421305,0.000009744431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8379449,0.01803133,0.1336206,0.001379797,0.0005882308,0.0003071893,0.0008279261,0.0009968311,0.006303214],"genre_scores_gemma":[0.9054523,0.008413102,0.07796759,0.0004471407,0.0001765511,0.0002321627,0.0009591627,0.0003047494,0.006047298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001846616,"threshold_uncertainty_score":0.006177545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06148070819335472,"score_gpt":0.2889692853829562,"score_spread":0.2274885771896015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}