{"id":"W4390333622","doi":"10.1182/blood.2023021752","title":"Developmental trajectories and cooperating genomic events define molecular subtypes of <i>BCR</i>::<i>ABL1</i>-positive ALL","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"José Carreras Leukämie-Stiftung; Deutsche Forschungsgemeinschaft; Government of Ontario","keywords":"Biology; CDKN2A; breakpoint cluster region; Cancer research; Fluorescence in situ hybridization; Myeloid; ABL; Myeloid leukemia; Immunology; Genetics; Gene; Tyrosine kinase; Receptor; Chromosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289196,0.0001148938,0.0001418464,0.0004748129,0.0001408282,0.000341001,0.00009744834,0.0001563441,0.0007557001],"category_scores_gemma":[0.0002203075,0.0001215575,0.0001048251,0.0003353143,0.0001675907,0.0001629696,0.000212807,0.0002086578,0.0002556347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001949503,"about_ca_system_score_gemma":0.0001155179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004882488,"about_ca_topic_score_gemma":0.0009530009,"domain_scores_codex":[0.999909,0.00001301398,0.000005505728,0.00002757133,0.0000167442,0.00002819111],"domain_scores_gemma":[0.999873,0.00002590693,0.0000554151,0.000007668174,0.00001774673,0.00002017405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000858368,0.00004753175,0.3541894,0.000065247,0.00003675549,0.0002416933,0.0006505345,0.0003713823,0.6306949,0.0003294987,0.0002687134,0.01224599],"study_design_scores_gemma":[0.000007879431,0.0001306576,0.977923,0.000005970518,0.00001922208,0.0005813118,0.0003577206,0.0006468741,0.01938897,0.0001462812,0.0007865917,0.000005513529],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990066,0.0001513899,0.0002773544,0.00001259739,7.613089e-7,0.000004793296,0.0002823528,0.000009068473,0.0002552008],"genre_scores_gemma":[0.9982311,0.0001306643,0.0003837133,0.00001347266,0.000002920274,0.00001547712,0.0009795132,0.000007229878,0.0002358014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007557001,"threshold_uncertainty_score":0.002528071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357706227410014,"score_gpt":0.2589549261742051,"score_spread":0.2453778639001049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}