{"id":"W4390344090","doi":"10.3324/haematol.2023.283776","title":"LNK/<i>SH2B3</i> as a novel driver in juvenile myelomonocytic leukemia","year":2023,"lang":"en","type":"article","venue":"Haematologica","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Deutsche Krebshilfe; Frank A. Campini Foundation; National Cancer Institute; National Institutes of Health; Children's Hospital of Philadelphia; Leukemia and Lymphoma Society","keywords":"Juvenile myelomonocytic leukemia; Cancer research; KRAS; Ruxolitinib; Biology; Myeloid; Haematopoiesis; Neuroblastoma RAS viral oncogene homolog; Internal medicine; Immunology; Mutation; Medicine; Genetics; Stem cell; Bone marrow; Myelofibrosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008053365,0.0002899559,0.0001468242,0.0004337018,0.0003040762,0.0003778801,0.0001667137,0.0003053707,0.0006737274],"category_scores_gemma":[0.0002330096,0.0001222539,0.0001669211,0.0003261082,0.0003196354,0.0001431244,0.00021191,0.0003187511,0.000167561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000342471,"about_ca_system_score_gemma":0.0002839589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001839824,"about_ca_topic_score_gemma":0.003863848,"domain_scores_codex":[0.9998856,0.00001203049,0.00001013575,0.00002122789,0.00003902098,0.0000320588],"domain_scores_gemma":[0.999854,0.00002451736,0.000052114,0.000008295179,0.000007958498,0.00005307566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005654246,0.00008216942,0.2185046,0.00009757971,0.00003577522,0.1980203,0.0005263428,0.0009615739,0.5438231,0.001168619,0.0008187916,0.03539578],"study_design_scores_gemma":[0.00008529326,0.0003238672,0.3873039,0.00003294579,0.0001111155,0.4543486,0.0004632463,0.003948089,0.1432301,0.000528127,0.00958596,0.0000388407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976284,0.0003079127,0.0006241831,0.00008599862,0.000007168756,0.00001293488,0.0001027642,0.00006004863,0.001170651],"genre_scores_gemma":[0.9992644,0.00008612684,0.0003384122,0.00002344319,0.000005069327,0.000003370922,0.00006511731,0.000007580351,0.0002062975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001839824,"threshold_uncertainty_score":0.003658235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0365812657277071,"score_gpt":0.3064503753839696,"score_spread":0.2698691096562625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}