{"id":"W4390348169","doi":"10.1038/s41375-023-02122-5","title":"In vitro evidence of synergistic efficacy with asciminib combined with reduced dose of ATP-binding pocket tyrosine kinase inhibitors according to the ABL1 kinase domain mutation profile","year":2023,"lang":"en","type":"article","venue":"Leukemia","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Tyrosine kinase; In vitro; Mutation; Pharmacology; Kinase; Tyrosine-kinase inhibitor; Protein kinase domain; Cancer research; Medicine; Biology; Biochemistry; Internal medicine; Mutant; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003303775,0.0004634329,0.0006073643,0.0003346,0.0001826551,0.0003104793,0.0002733876,0.0002297228,0.003301871],"category_scores_gemma":[0.0002768291,0.0001493672,0.0003985543,0.0003083034,0.0002096851,0.0001909542,0.0001663532,0.0007617279,0.000599589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002313255,"about_ca_system_score_gemma":0.0004294268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006782671,"about_ca_topic_score_gemma":0.001446827,"domain_scores_codex":[0.9998184,0.0000570189,0.00001355496,0.00002479011,0.00003228707,0.00005392318],"domain_scores_gemma":[0.999856,0.00005633395,0.00001676729,0.00001886336,0.00001632972,0.00003562635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02563472,0.005141524,0.002417669,0.000574274,0.0002722911,0.0002832031,0.00008564124,0.002583648,0.9009653,0.0005241361,0.003914913,0.05760272],"study_design_scores_gemma":[0.003225429,0.08081322,0.02463064,0.00005749357,0.0008969507,0.001762556,0.000138072,0.005037864,0.8656288,0.0003692234,0.01739187,0.00004790578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837912,0.007137795,0.001132651,0.0002856816,0.0002757195,0.000123162,0.001212891,0.0001025854,0.005938162],"genre_scores_gemma":[0.9935673,0.002471339,0.0009948845,0.00008178224,0.00007432154,0.00006424981,0.001300197,0.00001246118,0.001433639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003301871,"threshold_uncertainty_score":0.01104581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230207674304702,"score_gpt":0.2921074213278426,"score_spread":0.2690866538973724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}