{"id":"W4390350671","doi":"10.1016/j.ccell.2023.12.003","title":"Melanoma and microbiota: Current understanding and future directions","year":2023,"lang":"en","type":"review","venue":"Cancer Cell","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Environmental Health Sciences; Horizon 2020; EMD Serono; Direction Générale de l’offre de Soins; Genentech; Institut Gustave-Roussy; Institut Universitaire de France; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Université Paris-Saclay; Fondation pour la Recherche Médicale; Fondation Leducq; Agence Nationale de la Recherche; Institut National Du Cancer; AstraZeneca; Seres Therapeutics; Institut National de la Santé et de la Recherche Médicale; Pfizer; Incyte; Moderna; Juno Therapeutics; Astellas Pharma; Eisai; E-Rare; BeiGene; Ipsen; Jazz Pharmaceuticals; European Commission; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; Exelixis; Daiichi Sankyo Europe; National Cancer Institute; HORIZON EUROPE Framework Programme; Gilead Sciences; Labex Immuno-Oncology; National Institutes of Health; European Research Area Network on Cardiovascular Diseases; Regeneron Pharmaceuticals; Castle Biosciences; Therakos; Melanoma Research Alliance; Seerave Foundation; Association pour la Recherche sur le Cancer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Gut flora; Immunotherapy; Context (archaeology); Biology; Cancer immunotherapy; Immune system; Melanoma; Cancer; Immunology; Computational biology; Bioinformatics; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006273748,0.0002453327,0.0004394496,0.00004352622,0.0001380731,0.00003347719,0.00007509691,0.0002762752,0.0000182773],"category_scores_gemma":[0.00000174803,0.0002127068,0.000102821,0.00008910653,0.00005595681,0.00000175113,0.0001111992,0.0001808664,0.000006948319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000115717,"about_ca_system_score_gemma":0.0002257848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003622728,"about_ca_topic_score_gemma":0.0002711876,"domain_scores_codex":[0.9990701,0.00004262583,0.0001938808,0.0004357325,0.00003079405,0.0002268601],"domain_scores_gemma":[0.9995853,0.000009740947,0.0001123569,0.0001774942,0.00001540778,0.00009968712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000004683995,0.00002218528,0.00001328216,0.02415531,0.0001229398,0.000002531719,0.00008899595,1.968787e-8,0.001175929,0.00007004155,0.01795757,0.9563865],"study_design_scores_gemma":[0.0001203599,0.00003112058,0.000008105315,0.001149328,0.0001993787,0.00001928756,0.00006655913,1.457401e-7,0.00001893816,0.000004498642,0.9981564,0.0002258575],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009494433,0.9979954,0.000006562076,0.00004280789,0.001004791,0.0003068363,0.0002497059,0.00001587374,0.0002830442],"genre_scores_gemma":[0.000010336,0.9977011,0.00001644186,0.00002824507,0.001072404,0.0000403021,0.0002330072,0.00004877592,0.0008493584],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9801989,"threshold_uncertainty_score":0.8673933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07457797183921909,"score_gpt":0.3563010125318705,"score_spread":0.2817230406926514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}