{"id":"W4390367061","doi":"10.20944/preprints202312.2143.v1","title":"Development of Novel Bioluminescent Biosensors Monitoring Conformation and Activity of Merlin Tumor Suppressor","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Merlin (protein); Luciferase; Suppressor; Bioluminescence; Carcinogenesis; Biosensor; Cell growth; In vitro; Chemistry; Cell biology; Cell; Cancer; Cancer research; Biology; Biophysics; Biochemistry; Genetics; Transfection; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007119801,0.0006968869,0.000473652,0.0003491695,0.0001657827,0.0006093683,0.0009267579,0.001075079,0.0009571744],"category_scores_gemma":[0.0006329429,0.0003831862,0.0003328181,0.0002875027,0.000375347,0.0007343566,0.0005100598,0.001389581,0.0006525434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006750942,"about_ca_system_score_gemma":0.0002262527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002724061,"about_ca_topic_score_gemma":0.0004266817,"domain_scores_codex":[0.9996069,0.00006459395,0.00002485846,0.0001348303,0.0001121342,0.00005670267],"domain_scores_gemma":[0.999683,0.00008419595,0.00008570685,0.00003622863,0.00006051286,0.00005035573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002526923,0.00001192517,0.00005855789,0.00003059073,0.000003065625,0.00001503689,0.00001663529,0.00007641009,0.9981689,0.00017988,0.00005651094,0.001357203],"study_design_scores_gemma":[0.000008183889,0.00006037959,0.0002842568,0.000003915556,0.000004890698,0.00007663504,0.00001772252,0.003115041,0.9949077,0.00009386263,0.001417697,0.00000973203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7326598,0.003765644,0.2567442,0.0009850301,0.000268016,0.0001921419,0.001055116,0.001416268,0.002913735],"genre_scores_gemma":[0.7817525,0.002197189,0.2080888,0.0004084154,0.0000558756,0.0004012574,0.001293519,0.0001514079,0.005651115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001075079,"threshold_uncertainty_score":0.00489819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1342847372301491,"score_gpt":0.3401682288744475,"score_spread":0.2058834916442984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}