{"id":"W4390367090","doi":"10.1016/j.mad.2023.111898","title":"A feasibility study of the combination of intranasal insulin with oral semaglutide for cognition in older adults with metabolic syndrome at high dementia risk- Study rationale and design","year":2023,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute","funders":"","keywords":"Semaglutide; Medicine; Placebo; Dementia; Randomized controlled trial; Internal medicine; Type 2 diabetes; Diabetes mellitus; Endocrinology; Disease; Liraglutide; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006708958,0.003411047,0.005419824,0.001114867,0.001568909,0.001839645,0.001896868,0.003139321,0.005285273],"category_scores_gemma":[0.005268009,0.00223102,0.003654688,0.001277835,0.003091485,0.003086763,0.001566056,0.004650044,0.001663584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001475836,"about_ca_system_score_gemma":0.005369693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002614767,"about_ca_topic_score_gemma":0.003183207,"domain_scores_codex":[0.9953838,0.002526721,0.0003832212,0.0007333541,0.0003845512,0.0005882957],"domain_scores_gemma":[0.9961588,0.001194352,0.0006422937,0.0004849538,0.0003895706,0.001129874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9381378,0.04940119,0.002714439,0.0002887017,0.0006289526,0.00007740724,0.0001029732,0.0002298629,0.002245177,0.00009195205,0.0001359816,0.00594544],"study_design_scores_gemma":[0.3585815,0.6342072,0.004748359,0.00002174182,0.000859952,0.00003714853,0.00007217759,0.0002856106,0.0005510162,0.0001197306,0.000483533,0.00003203041],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9710538,0.001007954,0.00118701,0.0002931187,0.0003393689,0.02359527,0.0006913668,0.00006192427,0.001770008],"genre_scores_gemma":[0.9591162,0.001138048,0.005467477,0.001131332,0.001240252,0.02881568,0.0007606446,0.00003660401,0.00229381],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.006708958,"threshold_uncertainty_score":0.0354808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085197707005949,"score_gpt":0.2368320512607606,"score_spread":0.2159800741907011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}