{"id":"W4390397981","doi":"10.3390/cells13010073","title":"Sox10-Deficient Drug-Resistant Melanoma Cells Are Refractory to Oncolytic RNA Viruses","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Vemurafenib; Oncolytic virus; Melanoma; Cancer research; Biology; Downregulation and upregulation; Drug resistance; Virology; Gene; Genetics; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004550714,0.0002505332,0.0002324773,0.000172552,0.0001477187,0.00005862208,0.0005043314,0.0001443742,0.0001795199],"category_scores_gemma":[0.00004399617,0.0002421742,0.0001779125,0.0004188076,0.00008353646,0.000003569368,0.0002843314,0.0001587304,0.002601017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008278956,"about_ca_system_score_gemma":0.000192476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003262767,"about_ca_topic_score_gemma":0.0002374836,"domain_scores_codex":[0.9979012,0.0001390272,0.0002790581,0.0006254463,0.0004024285,0.0006528383],"domain_scores_gemma":[0.9986204,0.00004990718,0.00008922303,0.0008378926,0.0001118709,0.0002907181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007218874,0.00009902083,0.00004925204,0.00003110713,0.00004643604,0.00004361509,0.0001088879,0.000525191,0.9327313,0.000003011833,0.06432873,0.001311512],"study_design_scores_gemma":[0.0003660397,0.000986936,0.0002297749,0.00002165905,0.00001086555,7.212366e-7,0.0002115166,0.0000259396,0.8172103,0.0000130143,0.180668,0.0002551779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960096,0.0007132856,0.00002825057,0.000267681,0.0004223828,0.0004292521,0.0001123019,0.00006814136,0.001949099],"genre_scores_gemma":[0.9857826,0.0003027455,0.00007931641,0.001140179,0.0003172707,0.0000669449,0.00004651912,0.00007986769,0.01218452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1163393,"threshold_uncertainty_score":0.9981756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02525450717383051,"score_gpt":0.3010129002383225,"score_spread":0.275758393064492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}