{"id":"W4390397981","doi":"10.3390/cells13010073","title":"Sox10-Deficient Drug-Resistant Melanoma Cells Are Refractory to Oncolytic RNA Viruses","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Vemurafenib; Oncolytic virus; Melanoma; Cancer research; Biology; Downregulation and upregulation; Drug resistance; Virology; Gene; Genetics; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001293171,0.0002191378,0.0002661907,0.0001942128,0.0001925351,0.0004034673,0.0001038857,0.0001949588,0.002115828],"category_scores_gemma":[0.0001675294,0.0001262282,0.0002075147,0.0001757511,0.0002263577,0.0002035015,0.0001545824,0.000500792,0.0008270008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243927,"about_ca_system_score_gemma":0.000175901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001148239,"about_ca_topic_score_gemma":0.002107564,"domain_scores_codex":[0.999813,0.00001395409,0.00001480778,0.00004850694,0.00007859372,0.00003119068],"domain_scores_gemma":[0.9998067,0.00003661591,0.00006261912,0.00002812676,0.00002427441,0.00004165787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005253089,0.00001395561,0.0007239165,0.00002179469,0.00000532743,0.00005703794,0.0000202712,0.00008017172,0.9975764,0.00004761601,0.00006993802,0.001330985],"study_design_scores_gemma":[0.00001231911,0.00020426,0.02531779,0.00001167901,0.00001597687,0.0005978278,0.0001349425,0.002051414,0.964733,0.0001276541,0.00678442,0.000008752412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925548,0.0006133621,0.003097164,0.00008439205,0.000040801,0.00002631122,0.001974754,0.0001542446,0.00145415],"genre_scores_gemma":[0.9884977,0.0004666645,0.001948935,0.00007399481,0.000006747692,0.0000439868,0.003141246,0.00005883649,0.005761895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002115828,"threshold_uncertainty_score":0.007078111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02525450717383051,"score_gpt":0.3010129002383225,"score_spread":0.275758393064492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}