{"id":"W4390412143","doi":"10.3390/v16010057","title":"AAV Vectors Pseudotyped with Capsids from Porcine and Bovine Species Mediate In Vitro and In Vivo Gene Delivery","year":2023,"lang":"en","type":"article","venue":"Viruses","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Capsid; Adeno-associated virus; Genetic enhancement; Biology; Transgene; Virology; Gene delivery; Vectors in gene therapy; In vivo; Virus; Population; Vector (molecular biology); Gene; Genetics; Medicine; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004582825,0.0005510356,0.0003170916,0.0002920676,0.0002238447,0.0005152407,0.0002474123,0.0005646976,0.00101089],"category_scores_gemma":[0.0003123837,0.0002242029,0.0003736154,0.0001683473,0.0003526997,0.0003200001,0.000298148,0.0005619954,0.0007372354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002645779,"about_ca_system_score_gemma":0.0002563401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004524127,"about_ca_topic_score_gemma":0.0007315675,"domain_scores_codex":[0.999631,0.000105499,0.00003672691,0.00007870668,0.00008261419,0.0000654874],"domain_scores_gemma":[0.9998031,0.0000521959,0.00006581426,0.00002708205,0.000021999,0.00002977887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002613627,0.00001273854,0.0001622933,0.00005254627,0.000004098004,0.00004430684,0.00002255016,0.00005533382,0.9969222,0.0002615698,0.00005851454,0.002377738],"study_design_scores_gemma":[0.00001561053,0.0006697172,0.00243527,0.00002074412,0.00002476659,0.0009711139,0.00003480616,0.000682711,0.9800256,0.0001393504,0.01496714,0.00001312413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8168105,0.01377414,0.1559975,0.0004271476,0.0005151212,0.000489602,0.001007868,0.0007179747,0.01026008],"genre_scores_gemma":[0.9336872,0.004552192,0.05474592,0.0001525165,0.00006269536,0.0001355256,0.001355665,0.0001031217,0.005205307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00101089,"threshold_uncertainty_score":0.003381789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02041857939978122,"score_gpt":0.2647183802768583,"score_spread":0.2442998008770771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}