{"id":"W4390418610","doi":"10.1016/j.jconrel.2023.12.041","title":"Nogo-A neutralization in the central nervous system with a blood-brain barrier-penetrating antibody","year":2023,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Blood–brain barrier; Transferrin receptor; Central nervous system; Transcytosis; Monoclonal antibody; Antibody; Transferrin; Chemistry; Parenchyma; Immunology; Cell biology; Receptor; Neuroscience; Biology; Pathology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000282126,0.0004135009,0.0003061103,0.0001454762,0.0002036243,0.0003173911,0.0003491827,0.0004748165,0.0006555239],"category_scores_gemma":[0.000178774,0.0001736898,0.0003624669,0.00009134049,0.0003266936,0.0003222285,0.0001825308,0.0007720896,0.0001402293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002390492,"about_ca_system_score_gemma":0.0004275434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001185486,"about_ca_topic_score_gemma":0.001370485,"domain_scores_codex":[0.9998469,0.0000250198,0.0000104804,0.00002568446,0.00002553119,0.00006632968],"domain_scores_gemma":[0.9999374,0.00001513624,0.00001440715,0.000006072863,0.000007726861,0.00001922402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004446231,0.00006194001,0.00003880579,0.00005246318,0.00001543939,0.00006491635,0.00001801143,0.000135926,0.9974981,0.0001806702,0.00004598265,0.001443013],"study_design_scores_gemma":[0.0001584834,0.00287795,0.001285499,0.00001276016,0.00006766565,0.0003895873,0.00003341474,0.001921065,0.9919165,0.0001019444,0.001224356,0.0000108918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941956,0.001483679,0.003110685,0.00008039684,0.00006093127,0.00005708493,0.00005230211,0.00003912591,0.0009201529],"genre_scores_gemma":[0.9955623,0.0008021083,0.002188083,0.00006515937,0.00002060872,0.00003055977,0.00008476117,0.00001275687,0.001233554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001185486,"threshold_uncertainty_score":0.002357125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382484355808669,"score_gpt":0.2665238703376425,"score_spread":0.2526990267795558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}