{"id":"W4390430336","doi":"10.1002/anie.202313900","title":"The Molecular Basis of Human ALKBH3 Mediated RNA <i>N</i><sup><i>1</i></sup>‐methyladenosine (m<sup>1</sup>A) Demethylation","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; Shanghai Jiao Tong University; Major Research Plan; National Institutes of Health; National Key Research and Development Program of China; University of Toronto; Science and Technology Commission of Shanghai Municipality; Salt Science Research Foundation; Shanghai Education Development Foundation; National Institute of General Medical Sciences; Key Technologies Research and Development Program; University of Chicago; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Demethylation; RNA; Physics; Chemistry; Biochemistry; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004708839,0.0002191621,0.000171838,0.0001370739,0.0002315699,0.00006364061,0.0004560204,0.0002138649,0.0001336359],"category_scores_gemma":[0.0003332334,0.0001954024,0.000187377,0.0003772197,0.0001714019,0.00003134575,0.0001269136,0.0001611105,0.00004277251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006891659,"about_ca_system_score_gemma":0.00007574599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005561568,"about_ca_topic_score_gemma":0.000009304626,"domain_scores_codex":[0.9982002,0.00006877034,0.0004759634,0.0004247101,0.0005502808,0.0002800933],"domain_scores_gemma":[0.9986168,0.00009063543,0.0002557085,0.0004317173,0.0005190654,0.00008610438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006339583,0.00006764594,0.000277651,0.00001771711,0.0002062944,0.000003659005,0.0001297312,0.002912391,0.9589586,0.0007293691,0.03464937,0.001984154],"study_design_scores_gemma":[0.0006415984,0.00009117631,0.0007761936,0.00003121002,0.00004145759,0.00000457426,0.0002513018,0.001963689,0.9384809,0.0007689579,0.05674236,0.0002065908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787226,0.001387161,0.006979045,0.004679558,0.000531494,0.0004127793,0.0004797956,0.0001033942,0.006704189],"genre_scores_gemma":[0.9906499,0.001277837,0.0001330058,0.0003171176,0.00108514,0.000163952,0.00521736,0.00004253398,0.001113099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02209299,"threshold_uncertainty_score":0.796828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479665904937629,"score_gpt":0.2739360202252637,"score_spread":0.2591393611758874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}