{"id":"W4390430336","doi":"10.1002/anie.202313900","title":"The Molecular Basis of Human ALKBH3 Mediated RNA <i>N</i><sup><i>1</i></sup>‐methyladenosine (m<sup>1</sup>A) Demethylation","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; Shanghai Jiao Tong University; Major Research Plan; National Institutes of Health; National Key Research and Development Program of China; University of Toronto; Science and Technology Commission of Shanghai Municipality; Salt Science Research Foundation; Shanghai Education Development Foundation; National Institute of General Medical Sciences; Key Technologies Research and Development Program; University of Chicago; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Demethylation; RNA; Physics; Chemistry; Biochemistry; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005121729,0.0002084116,0.000100739,0.00005426939,0.0001546476,0.00010401,0.0001991406,0.0002621661,0.0009351978],"category_scores_gemma":[0.00009689404,0.0001061731,0.0002185529,0.00004440205,0.0001141629,0.0001045659,0.00008168024,0.000228342,0.0003705413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002781641,"about_ca_system_score_gemma":0.0001538467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000864836,"about_ca_topic_score_gemma":0.0008991581,"domain_scores_codex":[0.9999633,0.000005207962,0.000001821977,0.00001207863,0.000008756141,0.000008923834],"domain_scores_gemma":[0.999962,0.00000744426,0.00001148289,0.0000035341,0.000004896314,0.00001067656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007476166,0.00001385301,0.0002759219,0.0000279691,0.000004602724,0.00009829934,0.00001286255,0.0002763325,0.9982679,0.0002639714,0.00004216576,0.0006413903],"study_design_scores_gemma":[0.00001480967,0.0001220644,0.003850596,0.00000392929,0.00001057034,0.0001911108,0.0000195033,0.003721914,0.9906014,0.000186523,0.001271981,0.000005554085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931319,0.0007255545,0.003954469,0.0001182663,0.00002383825,0.00002482623,0.000351737,0.0000850539,0.001584358],"genre_scores_gemma":[0.9972804,0.0001669192,0.00147568,0.00002973306,0.000004982735,0.000009113041,0.0003752274,0.000008003713,0.0006499481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009351978,"threshold_uncertainty_score":0.003128529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479665904937629,"score_gpt":0.2739360202252637,"score_spread":0.2591393611758874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}