{"id":"W4390465908","doi":"10.3390/kinasesphosphatases2010002","title":"The Yin and Yang of IκB Kinases in Cancer","year":2023,"lang":"en","type":"article","venue":"Kinases and Phosphatases","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Crosstalk; Kinase; IκB kinase; Carcinogenesis; Immune system; Signal transduction; Biology; MAPK/ERK pathway; Suppressor; Inflammation; Phosphorylation; Cancer; Cancer research; PI3K/AKT/mTOR pathway; Cell biology; Neuroscience; NF-κB; Immunology; Genetics; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003969358,0.0003422055,0.0004051568,0.0004769785,0.0003217959,0.0007425525,0.0002614826,0.0004552994,0.002337228],"category_scores_gemma":[0.0002931849,0.00009183429,0.0002011048,0.0006077399,0.0007155198,0.0007546479,0.0007758393,0.00127077,0.0007290259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005579835,"about_ca_system_score_gemma":0.0009875497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005272034,"about_ca_topic_score_gemma":0.00119697,"domain_scores_codex":[0.9998705,0.00003525999,0.00001051514,0.00001786559,0.00004455963,0.00002122034],"domain_scores_gemma":[0.9999155,0.00001821924,0.00001807355,0.000004942493,0.00001693893,0.00002626605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003194873,0.00005331866,0.001525129,0.005902098,0.00008802136,0.0009882583,0.0003406059,0.001103371,0.02553298,0.1013577,0.07478268,0.7880064],"study_design_scores_gemma":[0.0000339465,0.000138818,0.003043195,0.0007622784,0.00003312066,0.00170473,0.0001986052,0.0002589675,0.003519785,0.03917723,0.9511061,0.00002319417],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002098602,0.9806367,0.001377721,0.007138835,0.002302941,0.000007986707,0.00003513393,0.00003574491,0.006366465],"genre_scores_gemma":[0.03543134,0.9514025,0.001354224,0.002020149,0.00252431,0.00001755013,0.0000374441,0.000009052757,0.00720337],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002337228,"threshold_uncertainty_score":0.007818758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556003018913705,"score_gpt":0.2824301666273595,"score_spread":0.2668701364382225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}