{"id":"W4390465908","doi":"10.3390/kinasesphosphatases2010002","title":"The Yin and Yang of IκB Kinases in Cancer","year":2023,"lang":"en","type":"article","venue":"Kinases and Phosphatases","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Crosstalk; Kinase; IκB kinase; Carcinogenesis; Immune system; Signal transduction; Biology; MAPK/ERK pathway; Suppressor; Inflammation; Phosphorylation; Cancer; Cancer research; PI3K/AKT/mTOR pathway; Cell biology; Neuroscience; NF-κB; Immunology; Genetics; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493352,0.00009855241,0.0001085571,0.00002803216,0.00008914548,0.00002138071,0.00008562303,0.00004837063,0.000009139982],"category_scores_gemma":[0.0001076329,0.00007297367,0.00002609904,0.0001235091,0.0001431486,0.000003388213,0.0001139025,0.00003858794,0.000001319109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003334227,"about_ca_system_score_gemma":0.00003155769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007878107,"about_ca_topic_score_gemma":0.0005639985,"domain_scores_codex":[0.9993791,0.00002928422,0.00014001,0.0002000488,0.00007366379,0.0001778857],"domain_scores_gemma":[0.9996216,0.00009430513,0.00005178666,0.0001671431,0.00002360391,0.00004161948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005526839,0.0001697706,0.1673654,0.0003949107,0.000111649,0.00009016195,0.000351315,0.0002788659,0.6730796,0.00322637,0.04171624,0.112663],"study_design_scores_gemma":[0.0005076221,0.0002253355,0.03073102,0.00009259097,0.00001895353,0.00000621314,0.0003073842,0.00005039078,0.9162634,0.0003579525,0.05126907,0.0001700841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954539,0.04470525,0.000002298353,0.0001820342,0.00007662295,0.00009761612,0.0003384119,0.000008993635,0.00004978731],"genre_scores_gemma":[0.9867283,0.0128064,0.00001901019,0.0000890729,0.00005891774,0.00003113044,0.0001215335,0.0000112127,0.0001343917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2431838,"threshold_uncertainty_score":0.297578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556003018913705,"score_gpt":0.2824301666273595,"score_spread":0.2668701364382225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}