{"id":"W4390485099","doi":"10.7150/ijbs.85276","title":"Polysaccharide isolated from<i> Grifola frondosa</i> eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses","year":2024,"lang":"en","type":"article","venue":"International Journal of Biological Sciences","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; State Key Laboratory of Advanced Metallurgy","keywords":"Grifola frondosa; Myeloid-derived Suppressor Cell; Cancer research; Downregulation and upregulation; CD8; Spleen; Bone marrow; Immune system; Immunology; Tumor microenvironment; Cancer; Cytotoxic T cell; Biology; Medicine; Suppressor; Polysaccharide; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005663511,0.0003056915,0.0001441248,0.0001620803,0.00009859908,0.0001269119,0.0001287382,0.000186084,0.001220019],"category_scores_gemma":[0.00006685899,0.00005093688,0.0002500172,0.00007231293,0.0001456312,0.0001329541,0.00009043333,0.0003426879,0.0002819986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001060235,"about_ca_system_score_gemma":0.0001559902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005200799,"about_ca_topic_score_gemma":0.0006061242,"domain_scores_codex":[0.9999774,0.000003573887,0.000001085857,0.000003475605,0.000005538661,0.000009092518],"domain_scores_gemma":[0.9999632,0.000005015244,0.00001031181,0.000003537803,0.000004912063,0.00001304561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006637834,0.00001820556,0.0001609558,0.00002551904,0.000003138101,0.00005875228,0.000003386737,0.00003734612,0.9979901,0.00007352143,0.00002058185,0.00154213],"study_design_scores_gemma":[0.00003137383,0.001068011,0.007541465,0.00001318924,0.00002160505,0.0006407244,0.00002339354,0.0002148845,0.9857807,0.0001562859,0.004502356,0.000006119399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927378,0.001313899,0.00227467,0.0002096449,0.00007564156,0.00002660046,0.0002355791,0.00006805485,0.003058041],"genre_scores_gemma":[0.9948618,0.0007626876,0.002349689,0.0001147258,0.00004287669,0.000006939549,0.0003927235,0.0000160114,0.001452485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001220019,"threshold_uncertainty_score":0.004081368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350911438281939,"score_gpt":0.2594265060473476,"score_spread":0.2459173916645283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}