{"id":"W4390498722","doi":"10.1038/s41467-023-43871-2","title":"Derivation of human primordial germ cell-like cells in an embryonic-like culture","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Division of Civil, Mechanical and Manufacturing Innovation; National Science Foundation; National Institutes of Health; Vetenskapsrådet; National Institute of Neurological Disorders and Stroke; Svenska Sällskapet för Medicinsk Forskning","keywords":"Biology; Embryonic stem cell; Induced pluripotent stem cell; Wnt signaling pathway; Germline; Paracrine signalling; Cell biology; Reprogramming; Germ cell; Germ line development; Genetics; Cell; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004563301,0.000232818,0.0002737645,0.000298868,0.0002485017,0.0003300788,0.0002869102,0.0003114227,0.001932362],"category_scores_gemma":[0.0002475537,0.0002063267,0.0002801351,0.0003036787,0.0001564725,0.00009333336,0.000280432,0.0005444254,0.002171303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000110631,"about_ca_system_score_gemma":0.0003386798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005617758,"about_ca_topic_score_gemma":0.001170174,"domain_scores_codex":[0.9998209,0.00001824936,0.00003025398,0.0000399676,0.00007011122,0.00002058204],"domain_scores_gemma":[0.9998343,0.00002500808,0.00001504789,0.00004971862,0.00004189201,0.00003405263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008961844,0.0000495603,0.0008847803,0.0001052594,0.00001109658,0.0003774873,0.0001008749,0.0003966462,0.9875382,0.0007642125,0.0008158354,0.008866394],"study_design_scores_gemma":[0.00004990361,0.0003738416,0.005190291,0.0000473235,0.00006580778,0.001363157,0.00005359184,0.002228205,0.9288657,0.0002439773,0.06149643,0.00002188794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6950236,0.006364757,0.2265717,0.000565412,0.0008271443,0.006044495,0.01684984,0.001647265,0.04610577],"genre_scores_gemma":[0.7888809,0.005404316,0.161615,0.0004790559,0.000103108,0.00159026,0.01759253,0.0002149019,0.02412003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001932362,"threshold_uncertainty_score":0.006464362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0182367864984479,"score_gpt":0.3316441041943334,"score_spread":0.3134073176958855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}